State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
J Mater Chem B. 2019 Dec 11;7(48):7776-7782. doi: 10.1039/c9tb01937e.
The design and preparation of a photoactive coordination polymer nanoplatform with tumor-related stimuli-activatability and biodegradability is highly desirable for achieving highly precise photodynamic therapy (PDT). Herein, novel "pre-photodynamic" nanoparticles (Fe-IBDP NPs) with a tumor microenvironment (TME)-activatable PDT and good biodegradability were synthesized by carrying out facile coordination assembly of an IBDP photosensitizer with an Fe3+ quenching agent. After being taken up by cancer cells, our "inactive" Fe-IBDP NPs were activated by the TME and as a result decomposed and released the photoactive carboxyl-functionalized diiodo-substituted BODIPY (IBDP) photosensitizer, which generated cytotoxic singlet oxygen (1O2) under light irradiation. By contrast, these NPs showed relatively low cytotoxicity in normal cells. This work also provided a feasible method for preparing the next generation of photoactive nanomedicines for use in precise phototherapy.
具有肿瘤相关刺激响应和生物可降解性的光活性配位聚合物纳米平台的设计和制备对于实现高精准光动力疗法（PDT）是非常理想的。在此，通过将 IBDP 光敏剂与 Fe3+ 猝灭剂进行简单的配位组装，合成了具有肿瘤微环境（TME）激活 PDT 和良好生物可降解性的新型“预 PDT”纳米颗粒（Fe-IBDP NPs）。在被癌细胞摄取后，我们的“非活性”Fe-IBDP NPs 被 TME 激活，并因此分解并释放出具有细胞毒性的、光活性的羧基功能化二碘取代 BODIPY（IBDP）光敏剂，其在光照下产生细胞毒性单线态氧（1O2）。相比之下，这些 NPs 在正常细胞中表现出相对较低的细胞毒性。这项工作还为制备下一代用于精准光疗的光活性纳米药物提供了一种可行的方法。
