1986年至2014年瑞典北部维生素D浓度的时间趋势：一项基于人群的横断面研究。

Time trends of vitamin D concentrations in northern Sweden between 1986 and 2014: a population-based cross-sectional study.

作者信息

Summerhays Eva, Eliasson Mats, Lundqvist Robert, Söderberg Stefan, Zeller Tanja, Oskarsson Viktor

机构信息

Sunderby Research Unit, Department of Public Health and Clinical Medicine, Umeå University, 901 87, Umeå, Sweden.

Research and Innovation Unit, Norrbotten County Council, Luleå, Sweden.

出版信息

Eur J Nutr. 2020 Oct;59(7):3037-3044. doi: 10.1007/s00394-019-02142-x. Epub 2019 Nov 21.

DOI:10.1007/s00394-019-02142-x

PMID:31754783

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7501112/

Abstract

PURPOSE

Vitamin D, produced through cutaneous photosynthesis or ingested via foods or supplements, has generated considerable research interest due to its potential health effects. However, epidemiological data on the time trends of vitamin D status are sparse, especially from northern Europe. We examined the time trend of vitamin D concentrations in northern Sweden between 1986 and 2014.

METHODS

We used data on 11,129 men and women (aged 25-74 years) from seven population-based surveys (the Northern Sweden MONICA study), recruited between 1986 and 2014. Serum vitamin D (25-hydroxyvitamin D) status was measured using a one-step immunoassay (Abbott Architect). Multivariable linear regression models, adjusted for age, sex, and a number of other variables, were used to estimate the time trend of vitamin D concentrations.

RESULTS

The mean value of vitamin D in the entire study population was 19.9 ng/mL [standard deviation (SD) 7.9], with lower values in men (19.4 ng/mL; SD 7.5) than in women (20.5 ng/mL; SD 8.2). Using the survey in 1986 as reference category, the multivariable-adjusted mean difference [95% confidence interval (CI)] in ng/mL was 2.7 (2.2, 3.3) in 1990, 3.2 (2.7, 3.7) in 1994, 1.6 (1.0, 2.1) in 1999, - 2.0 (- 2.5, - 1.4) in 2004, 1.0 (0.4, 1.5) in 2009, and 3.1 (2.5, 3.6) in 2014.

CONCLUSION

In this large cross-sectional study, we observed no clear upward or downward trend of vitamin D concentrations in northern Sweden between 1986 and 2014.

摘要

目的

通过皮肤光合作用产生或经食物或补充剂摄入的维生素D，因其潜在的健康影响而引发了大量研究兴趣。然而，关于维生素D水平时间趋势的流行病学数据较为匮乏，尤其是来自北欧的数据。我们研究了1986年至2014年瑞典北部维生素D浓度的时间趋势。

方法

我们使用了1986年至2014年间从七项基于人群的调查（瑞典北部莫尼卡研究）中招募的11,129名男性和女性（年龄在25 - 74岁之间）的数据。血清维生素D（25 - 羟基维生素D）水平采用一步免疫测定法（雅培Architect）进行测量。使用多变量线性回归模型，对年龄、性别和其他一些变量进行调整，以估计维生素D浓度的时间趋势。

结果

整个研究人群中维生素D的平均值为19.9 ng/mL [标准差（SD）7.9]，男性（19.4 ng/mL；SD 7.5）低于女性（20.5 ng/mL；SD 8.2）。以1986年的调查为参照类别，1990年多变量调整后的平均差值[95%置信区间（CI）]（单位：ng/mL）为2.7（2.2，3.3），1994年为3.2（2.7，3.7），1999年为1.6（1.0，2.1），2004年为 - 2.0（ - 2.5， - 1.4），2009年为1.0（0.4，1.5），2014年为3.1（2.5，3.6）。