The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China.
Graefes Arch Clin Exp Ophthalmol. 2020 Mar;258(3):675-682. doi: 10.1007/s00417-019-04507-8. Epub 2019 Nov 21.
Investigate morphological changes of macula and optic nerve head (ONH) in concomitant strabismic patients using optical coherence tomography (OCT) and confocal scanning laser ophthalmoscopy (CSLO).
A cross-sectional study conducted from April 2017 to February 2018 at the Zhongshan Ophthalmic Center, Sun Yat-sen University. Spectral-domain (SD)-OCT and CSLO were used to observe morphological changes of macula and ONH in concomitant strabismic patients with normal vision and healthy controls. In each subject, a 6-mm diameter zone centered at the fovea was scanned and topographical images of the ONH and peripapillary retina were generated. Fundus parameters were recorded and analyzed.
A total of 138 cases, including 29 patients with concomitant esotropia (ET), 38 constant exotropia (XT), 42 intermittent exotropia (IXT), and 29 healthy controls, were recruited. Compared with controls, OCT revealed that the thickness of nasal intraretinal layers (IRLs) in ET patients was significantly increased, particularly in ganglion cell layer (GCL) and inner nuclear layer (INL). In XT patients, the temporal half of outer retinal layers (ORLs) showed significant increases in thickness. CSLO findings revealed significant changes in the ONH of ET patients consisting of a thinner retinal nerve fiber layer (RNFL) and a decreased RNFL cross-sectional area, height variation contour, maximum contour depression, and contour line modulation (CLM) temporal-superior area. The nasal-superior cup area and rim volume in XT patients were significantly increased.
Topographical profiles of the macula and ONH in concomitant strabismic patients with normal vision present with specific regularities.
应用光学相干断层扫描（OCT）和共焦激光扫描检眼镜（CSLO）观察共同性斜视患者黄斑和视盘（ONH）的形态变化。
这是一项 2017 年 4 月至 2018 年 2 月在中山大学中山眼科中心进行的横断面研究。对伴有正常视力的共同性斜视患者和健康对照者进行频域（SD）-OCT 和 CSLO 检查，观察黄斑和 ONH 的形态变化。在每个受试者中，以黄斑为中心扫描直径为 6mm 的区域，并生成 ONH 和视盘周围视网膜的地形图。记录和分析眼底参数。
共纳入 138 例患者，包括 29 例共同性内斜视（内斜视）患者、38 例恒定性外斜视（外斜视）患者、42 例间歇性外斜视（外斜视）患者和 29 例健康对照者。与对照组相比，OCT 显示内视网膜层（IRL）的鼻侧厚度在 ET 患者中明显增加，尤其是在神经节细胞层（GCL）和内核层（INL）。在 XT 患者中，外视网膜层（ORL）的颞半部分厚度明显增加。CSLO 检查结果显示 ET 患者的 ONH 发生明显变化，包括视网膜神经纤维层（RNFL）变薄和 RNFL 横截面积、高度变化轮廓、最大轮廓凹陷和轮廓线调制（CLM）颞上区减小。XT 患者的鼻上杯区和边缘容积明显增加。
伴有正常视力的共同性斜视患者的黄斑和 ONH 地形图具有特定的规律。
