Andersen L P, Elsborg L, Justesen T
Dept. of Enterovirus, Statens Seruminstitut, Copenhagen, Denmark.
Scand J Gastroenterol. 1988 Aug;23(6):760-4. doi: 10.3109/00365528809093946.
Specimens from 153 consecutive patients were cultivated for C. pylori, and findings were correlated to the endoscopic findings. C. pylori was cultivated more frequently from males than from females. Culture-positive males had a high frequency of prepyloric abnormalities. No correlation between age or pH in gastric juice and cultivation of C. pylori was found. C. pylori was found significantly more often in patients with peptic ulcer and/or duodenitis than in patients with normal endoscopic findings. No differences could be detected between patients with gastritis or esophagitis and patients with normal endoscopic findings. C. pylori was found most frequently in the antral part of the stomach. It was cultivated significantly more often from patients with duodenal abnormalities than from patients with normal endoscopic findings. In less than half of the culture-positive patients with duodenal abnormalities we cultivated C. pylori from duodenal specimens. This study also showed C. pylori in esophageal specimens, which has not been previously described. Our results suggest that cultivation of C. pylori from duodenal specimens or gastric fluid samples gives no additional information beyond that obtained from the cultivation of antral biopsy specimens. It is our opinion that C. pylori, at least in some cases, may be a secondary infection.
对153例连续患者的标本进行幽门螺杆菌培养，并将结果与内镜检查结果进行关联分析。幽门螺杆菌在男性中的培养阳性率高于女性。培养阳性的男性患者胃幽门部异常的发生率较高。未发现年龄或胃液pH值与幽门螺杆菌培养之间存在相关性。与内镜检查结果正常的患者相比，消化性溃疡和/或十二指肠炎症患者中幽门螺杆菌的检出率显著更高。胃炎或食管炎患者与内镜检查结果正常的患者之间未检测到差异。幽门螺杆菌最常见于胃窦部。十二指肠异常患者中幽门螺杆菌的培养阳性率显著高于内镜检查结果正常的患者。在不到一半的十二指肠异常且培养阳性的患者中，十二指肠标本培养出了幽门螺杆菌。本研究还在食管标本中发现了幽门螺杆菌，这在之前未见报道。我们的结果表明，从十二指肠标本或胃液样本中培养幽门螺杆菌，除了从胃窦活检标本培养中获得的信息外，没有提供额外的信息。我们认为，幽门螺杆菌至少在某些情况下可能是继发感染。
