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IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids.

作者信息

Dijk F Nicole, Vijverberg Susanne J, Hernandez-Pacheco Natalia, Repnik Katja, Karimi Leila, Mitratza Marianna, Farzan Niloufar, Nawijn Martijn C, Burchard Esteban G, Engelkes Marjolein, Verhamme Katia M, Potočnik Uroš, Pino-Yanes Maria, Postma Dirkje S, Maitland-van der Zee Anke-Hilse, Koppelman Gerard H

机构信息

Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Department of Respiratory Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

出版信息

Allergy. 2020 Apr;75(4):984-989. doi: 10.1111/all.14125. Epub 2019 Dec 17.

DOI:
10.1111/all.14125
PMID:31755552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7176513/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bec/7217025/42d1096f61ea/ALL-75-984-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bec/7217025/42d1096f61ea/ALL-75-984-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bec/7217025/42d1096f61ea/ALL-75-984-g001.jpg

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本文引用的文献

1
Genetic regulation of methylation and IL1RL1-a protein levels in asthma.哮喘中甲基化和 IL1RL1-a 蛋白水平的遗传调控。
Eur Respir J. 2018 Mar 8;51(3). doi: 10.1183/13993003.01377-2017. Print 2018 Mar.
2
A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis.功能性 IL1RL1 变体调节溃疡性结肠炎中皮质类固醇诱导的 sST2 表达。
Sci Rep. 2017 Aug 31;7(1):10180. doi: 10.1038/s41598-017-10465-0.
3
Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium.儿童哮喘多民族药物基因组学联盟的基本原理与设计
Int J Mol Sci. 2023 Apr 10;24(8):7029. doi: 10.3390/ijms24087029.
4
Asthma Exacerbations: The Genes Behind the Scenes.哮喘恶化：幕后的基因。
J Investig Allergol Clin Immunol. 2023 Apr 18;33(2):76-94. doi: 10.18176/jiaci.0878. Epub 2022 Nov 24.
5
The Genetic Factors of the Airway Epithelium Associated with the Pathology of Asthma.气道上皮与哮喘病理相关的遗传因素。
Genes (Basel). 2022 Oct 15;13(10):1870. doi: 10.3390/genes13101870.
6
Recent insights in the role of biomarkers in severe asthma management.生物标志物在重度哮喘管理中作用的最新见解。
Front Med (Lausanne). 2022 Sep 26;9:992565. doi: 10.3389/fmed.2022.992565. eCollection 2022.
7
Current Understanding of Asthma Pathogenesis and Biomarkers.当前对哮喘发病机制和生物标志物的认识。
Cells. 2022 Sep 5;11(17):2764. doi: 10.3390/cells11172764.
8
Interleukin 1 receptor-like 1 rs13408661/13431828 polymorphism is associated with persistent post-bronchiolitis asthma at school age.白细胞介素 1 受体样 1 rs13408661/13431828 多态性与学龄期支气管肺炎后持续性哮喘有关。
Acta Paediatr. 2022 Mar;111(3):628-635. doi: 10.1111/apa.16176. Epub 2021 Nov 18.
9
Pharmacogenetics of Pediatric Asthma: Current Perspectives.小儿哮喘的药物遗传学：当前观点
Pharmgenomics Pers Med. 2020 Mar 18;13:89-103. doi: 10.2147/PGPM.S201276. eCollection 2020.
Pharmacogenomics. 2017 Jul;18(10):931-943. doi: 10.2217/pgs-2017-0035. Epub 2017 Jun 22.
4
Pharmacogenetics of asthma: toward precision medicine.哮喘的药物遗传学：迈向精准医学
Curr Opin Pulm Med. 2017 Jan;23(1):12-20. doi: 10.1097/MCP.0000000000000335.
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asthma risk variants regulate airway type 2 inflammation.哮喘风险变异调控气道 2 型炎症。
JCI Insight. 2016 Sep 8;1(14):e87871. doi: 10.1172/jci.insight.87871.
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No evidence of large genetic effects on steroid response in asthma patients.没有证据表明哮喘患者的类固醇反应存在较大的遗传影响。
J Allergy Clin Immunol. 2017 Mar;139(3):797-803.e7. doi: 10.1016/j.jaci.2016.05.032. Epub 2016 Jul 5.
7
The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders.白细胞介素-33/白细胞介素-1受体样蛋白1轴在过敏性疾病中肥大细胞和嗜碱性粒细胞活化中的作用。
Mol Immunol. 2015 Jan;63(1):80-5. doi: 10.1016/j.molimm.2014.06.018. Epub 2014 Jul 10.
8
Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma.聚焦嗜酸性粒细胞：非过敏性哮喘中的嗜酸性气道炎症
Nat Med. 2013 Aug;19(8):977-9. doi: 10.1038/nm.3300.
9
Decoding asthma: translating genetic variation in IL33 and IL1RL1 into disease pathophysiology.解码哮喘：将 IL33 和 IL1RL1 中的遗传变异转化为疾病病理生理学。
J Allergy Clin Immunol. 2013 Mar;131(3):856-65. doi: 10.1016/j.jaci.2012.11.028. Epub 2013 Feb 4.
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T-helper type 2-driven inflammation defines major subphenotypes of asthma.2型辅助性T细胞驱动的炎症反应定义了哮喘的主要亚表型。
Am J Respir Crit Care Med. 2009 Sep 1;180(5):388-95. doi: 10.1164/rccm.200903-0392OC. Epub 2009 May 29.