Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland.
Center for Life Course Health Research, University of Oulu, Oulu, Finland.
Addiction. 2020 May;115(5):888-900. doi: 10.1111/add.14889. Epub 2020 Jan 17.
To assess the associations of intoxication frequency and number of drinks needed to become intoxicated in mid-adolescence with onset of psychiatric disorders in early adulthood.
DESIGN, SETTING AND PARTICIPANTS: Prospective cohort study in Northern Finland, with people from the Northern Finland Birth Cohort 1986 who self-reported adolescent alcohol use: 6548 subjects (69.4% of the original sample). Data on alcohol use were collected using questionnaires at ages 15-16 years.
Outcomes were any non-organic psychosis, mood disorder, anxiety disorder, any substance use disorder (SUD) and all the studied psychiatric disorders in early adulthood gathered from nation-wide health care, pension and insurance registers. Number of drinks needed to become intoxicated was categorized into three classes: (1) no alcohol use or intoxication, and (2) low and (3) high alcohol tolerance (more than seven/nine drinks for females/males) groups. Similarly, intoxication frequency was divided into three classes: (1) never, (2) one to two times and (3) three or more times during the past 30 days. Information regarding gender, family type, other drug use, psychopathology using Youth Self-Report (YSR) total score and parental psychiatric disorders were used as covariates.
In the multivariable analyses, both low [odds ratio (OR) = 3.0, 95% confidence interval (CI) = 1.3-6.7, P-value = 0.009] and high (OR = 4.4, 95% CI = 1.8-11.1, P-value = 0.001) alcohol tolerance were associated with increased risk of SUD. More frequent intoxication was associated with increased frequency of SUD (OR = 3.9, 95% CI = 2.0-7.3, P-value < 0.001) and mood disorder (OR = 1.6, 95% CI = 1.1-2.3, P-value = 0.008). The latter was attenuated after adjusting with concurrent psychopathology (YSR) and other drug use.
Both higher alcohol tolerance and frequent intoxication in adolescence appear to be associated with increased risk of future substance use disorder.
评估青少年中期醉酒频率和醉酒所需酒量与成年早期精神障碍发病的相关性。
设计、地点和参与者：本研究为芬兰北部的前瞻性队列研究，研究对象为芬兰北部出生队列 1986 年的人群，他们自我报告了青少年时期的饮酒情况：6548 名受试者（原始样本的 69.4%）。使用问卷在 15-16 岁时收集饮酒数据。
使用全国性的医疗保健、养老金和保险登记处获取成年早期任何非器质性精神病、心境障碍、焦虑障碍、任何物质使用障碍（SUD）和所有研究的精神障碍的结局。醉酒所需酒量分为三类：（1）无酒精使用或醉酒，（2）低和（3）高酒精耐受（女性/男性超过 7/9 杯）组。类似地，醉酒频率分为三类：（1）从不，（2）1-2 次，（3）过去 30 天内 3 次或更多次。性别、家庭类型、其他药物使用、使用青少年自我报告（YSR）总分评估的精神病理学以及父母的精神障碍等信息被用作协变量。
在多变量分析中，低（比值比 [OR] = 3.0，95%置信区间 [CI] = 1.3-6.7，P 值 = 0.009）和高（OR = 4.4，95% CI = 1.8-11.1，P 值 = 0.001）酒精耐受均与 SUD 风险增加相关。更频繁的醉酒与 SUD（OR = 3.9，95% CI = 2.0-7.3，P 值 <0.001）和心境障碍（OR = 1.6，95% CI = 1.1-2.3，P 值 = 0.008）的频率增加相关。调整同时存在的精神病理学（YSR）和其他药物使用后，后者减弱。
青少年时期较高的酒精耐受和更频繁的醉酒似乎都与未来物质使用障碍的风险增加有关。
