孕期邻苯二甲酸酯暴露与血压的关系。
Association between phthalate exposure and blood pressure during pregnancy.
机构信息
Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, China.
State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China.
出版信息
Ecotoxicol Environ Saf. 2020 Feb;189:109944. doi: 10.1016/j.ecoenv.2019.109944. Epub 2019 Nov 20.
BACKGROUND
Phthalates are endocrine disrupting chemicals (EDCs) that pose a serious hazard to the human health. Many epidemiological studies revealed a relationship between phthalates exposure and blood pressure in general population, while the relationship in pregnant women remains unknown.
OBJECTIVES
Aimed to elucidate whether phthalate exposure is associated with blood pressure among pregnant women.
METHODS
This study included 636 participants from Wuhan, China. Urine samples were conducted repeatedly in three trimesters, and 9 phthalates were measured in these samples. After each urine was sampled, all the participants completed blood pressure measurements. Associations between repeated measurements of phthalate concentration and blood pressure were evaluated by using generalized estimating equations. Stratified analysis by fetus gender was conducted.
RESULTS
Among the pregnant women with male fetuses, mono-i-butyl phthalate (MiBP) exposed in the 1st trimester was associated with the increased diastolic blood pressure (DBP) measured in the 2nd trimester, while the environmental risk score (ERS) measured in the 1st and 2nd trimester was positively associated with systolic blood pressure (SBP) and DBP in the 2nd trimester. No significant relationships were observed among all the population or pregnant women with female fetuses.
CONCLUSIONS
Exposure to higher levels of MiBP may be related to increased blood pressure during pregnancy in pregnant women with male fetuses.
背景
邻苯二甲酸酯是内分泌干扰化学物质（EDCs），对人类健康构成严重威胁。许多流行病学研究表明，邻苯二甲酸酯暴露与一般人群的血压之间存在关系，而孕妇中的这种关系尚不清楚。
目的
旨在阐明孕妇邻苯二甲酸酯暴露与血压之间是否存在关联。
方法
本研究纳入了来自中国武汉的 636 名参与者。在三个孕期中反复进行尿液样本采集，并在这些样本中测量了 9 种邻苯二甲酸酯。每次采集尿液后，所有参与者都完成了血压测量。使用广义估计方程评估邻苯二甲酸酯浓度的重复测量与血压之间的关联。按胎儿性别进行分层分析。
结果
在怀有男胎的孕妇中，第 1 孕期暴露的单丁基邻苯二甲酸酯（MiBP）与第 2 孕期测量的舒张压（DBP）升高有关，而第 1 孕期和第 2 孕期测量的环境风险评分（ERS）与第 2 孕期的收缩压（SBP）和 DBP 呈正相关。在所有人群或怀有女胎的孕妇中均未观察到显著相关性。
结论
在怀有男胎的孕妇中，较高水平的 MiBP 暴露可能与孕期血压升高有关。
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