[法国单纯性尿路感染中大肠杆菌对甲氧苄啶的耐药现状]
[Current state of resistance of E. coli to trimethoprim in uncomplicated urinary tract infections in France].
作者信息
Mabboux P, Rouveix B
机构信息
Laboratoires de biologie médicale, centre de biologie et de cytogénétique médicales, 27000 Evreux, France.
BR Consultant, 34, rue de Meudon, 92100 Boulogne-Billancourt, France.
出版信息
Prog Urol. 2019 Dec;29(16):943-946. doi: 10.1016/j.purol.2019.09.003. Epub 2019 Nov 19.
OBJECTIVE
The objective of this study was to assess the level of resistance of trimethoprim alone (TMP) with respect to E. coli strains isolated from the urines of women with simple acute cystitis in community.
PATIENTS AND METHODS
Prospective study realized for 9 months in 2017-18. A total of 351 urine samples were analyzed. Culture has been made according to the usual techniques and antibiogram was carried out according to the recommendations of the CA-SFM.
RESULTS
The rate of resistance to TMP was 16.5% (58/351). Only 11 strains of E. coli (3%) producing ESBL were found, 5 of which were sensitive to TMP.
CONCLUSION
The resistance rate of E. coli to TMP remains below 20%, the threshold for choosing a probabilistic treatment of a non-serious infection. Considering the good tolerance of TMP and its weak effect on the microbiota during a short treatment, one can propose TMP alone in the probabilistic treatment of simple acute cystitis.
目的
本研究的目的是评估单独使用甲氧苄啶（TMP）对从社区单纯性急性膀胱炎女性尿液中分离出的大肠杆菌菌株的耐药水平。
患者与方法
2017 - 18年进行了为期9个月的前瞻性研究。共分析了351份尿液样本。按照常规技术进行培养，并根据法国微生物学会（CA - SFM）的建议进行药敏试验。
结果
对TMP的耐药率为16.5%（58/351）。仅发现11株产超广谱β-内酰胺酶（ESBL）的大肠杆菌菌株（3%），其中5株对TMP敏感。
结论
大肠杆菌对TMP的耐药率仍低于20%，这是选择非严重感染概率性治疗的阈值。考虑到TMP耐受性良好且在短疗程中对微生物群影响较小，在单纯性急性膀胱炎的概率性治疗中可单独使用TMP。
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