Radiation Oncology, University Hospital of Martinique, Fort-de-France 97200 Martinique, France.
Radiation Oncology, University Hospital of Martinique, Fort-de-France 97200 Martinique, France.
Med Dosim. 2020;45(2):186-189. doi: 10.1016/j.meddos.2019.10.004. Epub 2019 Nov 19.
Radiation therapy needs to balance between delivering a high dose to targets and the lowest possible dose to the organs at risk. Dose-volume histograms (DVHs) summarize the distribution of radiation doses in the irradiated structures. The interpretation can however be a challenge when the number of structures is high. We propose the use of a simple summary metric. We define the mean absolute dose deviation (MADD) as the average of absolute differences between a DVH and a reference dose. The properties are evaluated through numerical analysis. Calculus trivially shows the identity of the MADD and the area between curves, between DVH and reference dose. Computation of the MADD is the same regardless of structures' designation, whether organ at risk or target, on the same dose scale. Basic calculus properties open the perspective of applying the MADD to the evaluation of treatment plans.
放射治疗需要在向目标部位提供高剂量与对风险器官给予尽可能低剂量之间取得平衡。剂量体积直方图（DVH）总结了照射结构内的辐射剂量分布。然而，当结构数量较高时，解释可能具有挑战性。我们建议使用简单的汇总指标。我们将平均绝对剂量偏差（MADD）定义为 DVH 与参考剂量之间的绝对差值的平均值。通过数值分析评估这些特性。微积分可以轻而易举地证明 MADD 与 DVH 和参考剂量之间的曲线下面积之间的同一性。无论结构是风险器官还是目标，MADD 的计算都相同，只要剂量刻度相同。微积分的基本特性为将 MADD 应用于治疗计划评估开辟了前景。
