Ait Boudaoud Amel, Rives-Lange Claire, Perregaux Jean François, Radu Alina, Messager-Josipowicz Diane, Barsamian Charles, Carette Claire, Czernichow Sébastien
AP-HP, Hôpital Européen Georges-Pompidou, centre spécialisé Obésité IdF Sud, service de nutrition, 20, rue Leblanc, 75015 Paris, France; Université de Paris, 20, rue Leblanc, 75015 Paris, France.
AP-HP, Hôpital Européen Georges-Pompidou, centre spécialisé Obésité IdF Sud, service de nutrition, 20, rue Leblanc, 75015 Paris, France; Université de Paris, 20, rue Leblanc, 75015 Paris, France.
Presse Med. 2019 Dec;48(12):1496-1501. doi: 10.1016/j.lpm.2019.10.026. Epub 2019 Nov 19.
Nonalcoholic fatty liver disease (NAFLD) is strongly associated with obesity and insulin resistance. There is currently no pharmacological treatment validated in steatosis. The combination of weight loss and adequate physical activity can improve liver steatosis. In randomized trials and cohort studies, a weight loss of at least 7% and a diet approaching the Mediterranean diet have been associated with an improvement in hepatic fat content, an improvement in hepatic biomarkers, and regression of histological signs of steatosis. Bariatric surgery by losing weight can lead to an improvement in hepatic fat content.
非酒精性脂肪性肝病（NAFLD）与肥胖和胰岛素抵抗密切相关。目前尚无经证实对脂肪变性有效的药物治疗方法。减肥与适当的体育活动相结合可改善肝脏脂肪变性。在随机试验和队列研究中，至少7%的体重减轻以及接近地中海饮食的饮食方式与肝脏脂肪含量的改善、肝脏生物标志物的改善以及脂肪变性组织学征象的消退有关。通过减肥进行的减重手术可使肝脏脂肪含量得到改善。
