Lynch Laboratories, Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Methods Mol Biol. 2020;2071:27-47. doi: 10.1007/978-1-4939-9857-9_2.
ToxoDB is a free online resource that provides access to genomic and functional genomic data. All data is made available through an intuitive queryable interface that enables scientists to build in silico experiments and develop testable hypothesis. The resource contains 32 fully sequenced and annotated genomes, with genomic sequence from multiple strains available for variant detection and copy number variation analysis. In addition to genomic sequence data, ToxoDB contains numerous functional genomic datasets including microarray, RNAseq, proteomics, ChIP-seq, and phenotypic data. In addition, results from a number of whole-genome analyses are incorporated including mapping to orthology clusters which allows users to leverage phylogenetic relationships in their analyses. Integration of primary data is made possible through a private galaxy interface and custom export tools that allow users to interrogate their own results in the context of all other data in the database.
ToxoDB 是一个免费的在线资源,提供基因组和功能基因组数据的访问。所有数据都通过直观的可查询界面提供,使科学家能够进行计算机实验并提出可测试的假设。该资源包含 32 个完整测序和注释的基因组,提供了多种菌株的基因组序列,用于变体检测和拷贝数变异分析。除了基因组序列数据,ToxoDB 还包含许多功能基因组数据集,包括微阵列、RNAseq、蛋白质组学、ChIP-seq 和表型数据。此外,还整合了许多全基因组分析的结果,包括映射到同源聚类,允许用户在分析中利用系统发育关系。通过私有 Galaxy 界面和自定义导出工具实现了原始数据的集成,允许用户在数据库中的所有其他数据的上下文中查询他们自己的结果。