Basenko Evelina Y, Pulman Jane A, Shanmugasundram Achchuthan, Harb Omar S, Crouch Kathryn, Starns David, Warrenfeltz Susanne, Aurrecoechea Cristina, Stoeckert Christian J, Kissinger Jessica C, Roos David S, Hertz-Fowler Christiane
Centre for Genomic Research, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
J Fungi (Basel). 2018 Mar 20;4(1):39. doi: 10.3390/jof4010039.
FungiDB (fungidb.org) is a free online resource for data mining and functional genomics analysis for fungal and oomycete species. FungiDB is part of the Eukaryotic Pathogen Genomics Database Resource (EuPathDB, eupathdb.org) platform that integrates genomic, transcriptomic, proteomic, and phenotypic datasets, and other types of data for pathogenic and nonpathogenic, free-living and parasitic organisms. FungiDB is one of the largest EuPathDB databases containing nearly 100 genomes obtained from GenBank, Genome Database (AspGD), The Broad Institute, Joint Genome Institute (JGI), Ensembl, and other sources. FungiDB offers a user-friendly web interface with embedded bioinformatics tools that support custom in silico experiments that leverage FungiDB-integrated data. In addition, a Galaxy-based workspace enables users to generate custom pipelines for large-scale data analysis (e.g., RNA-Seq, variant calling, etc.). This review provides an introduction to the FungiDB resources and focuses on available features, tools, and queries and how they can be used to mine data across a diverse range of integrated FungiDB datasets and records.
真菌数据库(fungidb.org)是一个免费的在线资源库,用于真菌和卵菌物种的数据挖掘和功能基因组学分析。真菌数据库是真核病原体基因组数据库资源(EuPathDB,eupathdb.org)平台的一部分,该平台整合了基因组、转录组、蛋白质组和表型数据集,以及致病和非致病、自由生活和寄生生物的其他类型数据。真菌数据库是最大的EuPathDB数据库之一,包含从GenBank、基因组数据库(AspGD)、布罗德研究所、联合基因组研究所(JGI)、Ensembl和其他来源获得的近100个基因组。真菌数据库提供了一个用户友好的网络界面,带有嵌入式生物信息学工具,支持利用真菌数据库整合数据进行定制的计算机模拟实验。此外,基于Galaxy的工作区使用户能够生成用于大规模数据分析(如RNA测序、变异检测等)的定制管道。本综述介绍了真菌数据库资源,并重点介绍了可用的功能、工具和查询,以及如何使用它们来挖掘各种整合的真菌数据库数据集和记录中的数据。