Sjoblad R D
Hazard Evaluation Division, U.S. Environmental Protection Agency, Washington, D.C. 20460.
Toxicol Ind Health. 1988 Sep;4(3):391-5.
The thoughts presented above comprise a possible approach for revising Subdivision F guidelines with respect to testing of chemical pesticides as immunotoxicants. The main points of this report can be summarized as follows: 1. The tier system approach to Subdivision M guidelines allows for an effective screen (Tier I), and for in-depth (Tier II) evaluation of biochemical pesticides as immunotoxic agents. 2. Subchronic and chronic studies in Subdivision F guidelines can be modified to provide a more effective screen for evaluating the immunotoxic potential of chemical pesticides. 3. Addition to Subdivision F of studies to measure certain specific and non-specific cell-mediated immune responses might be considered appropriate for an immunotoxicity screen and, if included, would render Subdivision F data requirements analogous to those of Subdivision M. 4. When considered necessary, further studies can be done with chemical pesticides to provide sufficient data for an in-depth immunotoxicological risk evaluation. These studies would not necessarily be performed routinely (i.e., would not be included as data requirements in Subdivision F), but rather would be reserved for pesticides for which the immune system is shown to be a sensitive target of toxicity.
上述观点构成了一种修订F分部关于化学农药作为免疫毒性物质检测指南的可行方法。本报告的要点可总结如下：1. M分部指南中的分层系统方法可对生化农药作为免疫毒性物质进行有效筛选（一级）和深入（二级）评估。2. F分部指南中的亚慢性和慢性研究可进行修改，以便更有效地筛选化学农药的免疫毒性潜力。3. 考虑在F分部增加测量某些特定和非特异性细胞介导免疫反应的研究，可能适合用于免疫毒性筛选，如果纳入，将使F分部的数据要求与M分部类似。4. 如有必要，可对化学农药开展进一步研究，以提供足够的数据进行深入的免疫毒理学风险评估。这些研究不一定常规进行（即不会作为F分部的数据要求纳入），而是保留给免疫系统显示为毒性敏感靶点的农药。
