Allott B S, Dittmer K E, Kenyon A G, Elder P A
North Canterbury Veterinary Clinics, Amberley, New Zealand.
School of Veterinary Science, Massey University, Palmerston North, New Zealand.
N Z Vet J. 2020 May;68(3):193-197. doi: 10.1080/00480169.2019.1696719. Epub 2019 Dec 11.
To determine if vitamin D treatment reduced the incidence of vaginal prolapse in pregnant sheep on a North Canterbury sheep breeding property. Pregnant ewes from a single farm were allocated to three treatment groups in May 2018. At this time, the first group (EarlyVitADE; n = 512) received an I/M 1 mL dose of 500,000 IU/mL vitamin D, 60,000 IU/mL vitamin A, and 25 mg/mL vitamin E. This was repeated in July 2018, when the second group (LateVitADE; n = 695) also received the same treatment. The third group (n = 737) were untreated controls. All cases of vaginal prolapse on the property were recorded from pregnancy diagnosis in June 2018 until ewes were set-stocked in August 2018. The planned start of lambing was 10 August 2018. During the period of observation, vaginal prolapses were recorded in 3/699 (0.4%) 2-year-old ewes, and the odds of vaginal prolapse were not associated with treatment group in these ewes (p > 0.3). Amongst ewes aged ≥3 years, during the same period, there were 6/333 (1.8%), 6/443 (1.4%) and 25/469 (5.3%) cases in the EarlyVitADE, LateVitADE and control groups, respectively. Compared to control ewes, the odds of vaginal prolapse were reduced in both the EarlyVitADE (OR = 0.37; 95% CI = 0.15-0.92) and LateVitADE (OR = 0.25; 95% CI = 0.10-0.62) treatment groups. In this preliminary study, administration of injectable vitamins A, D, and E to pregnant ewes reduced the incidence of vaginal prolapse during the period from pregnancy diagnosis to set-stocking on one North Canterbury hill-country farm. Due to the restricted data collection period, this investigation should be replicated to better quantify the repeatability of the observed treatment effect over the complete lambing period.
为确定维生素D治疗是否能降低北坎特伯雷一个绵羊养殖场上怀孕母羊阴道脱垂的发生率。2018年5月，将来自单个农场的怀孕母羊分配到三个治疗组。此时，第一组（EarlyVitADE；n = 512）接受1毫升肌肉注射剂量的500,000国际单位/毫升维生素D、60,000国际单位/毫升维生素A和25毫克/毫升维生素E。2018年7月重复该操作，第二组（LateVitADE；n = 695）也接受相同治疗。第三组（n = 737）为未治疗的对照组。记录该养殖场从2018年6月妊娠诊断到2018年8月母羊圈养期间所有阴道脱垂病例。计划产羔开始时间为2018年8月10日。在观察期间，3/699（0.4%）的2岁母羊出现阴道脱垂，这些母羊阴道脱垂的几率与治疗组无关（p > 0.3）。在≥3岁的母羊中，同期EarlyVitADE组、LateVitADE组和对照组分别有6/333（1.8%）、6/443（1.4%）和25/469（5.3%）的病例。与对照母羊相比，EarlyVitADE组（OR = 0.37；95% CI = 0.15 - 0.92）和LateVitADE组（OR = 0.25；95% CI = 0.10 - 0.62）阴道脱垂的几率均降低。在这项初步研究中，对怀孕母羊注射维生素A、D和E可降低北坎特伯雷一个山地农场从妊娠诊断到圈养期间阴道脱垂的发生率。由于数据收集期有限，应重复此项调查，以更好地量化在整个产羔期观察到的治疗效果的可重复性。
