Department of Obstetrics and Gynecology, Faculty of Medicine, University Hospital Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
PLoS One. 2022 Aug 4;17(8):e0271467. doi: 10.1371/journal.pone.0271467. eCollection 2022.
The pathophysiology of pelvic organ prolapse (POP) has not been fully elucidated, although accumulating evidence suggests that oxidative stress is involved. The present systematic review comprehensively discusses this topic.
The PubMed/Medline, Scopus, and Web of Science databases were searched for relevant studies published up to May 2021. This systematic review was registered in the PROSPERO database (registration number CRD42021242240). Two independent researchers screened and selected articles that fulfilled predefined inclusion criteria, performed a quality assessment, and extracted the relevant data. Of 901 original articles retrieved, 8 fulfilled the selection criteria and were included in the review.
Elevated levels of markers of oxidative stress, such as advanced glycation end products, hydroxynonenal and hydroxydeoxyguanosine, were found in various parts of the pelvic floor of patients with POP. Accordingly, the levels of glutathione peroxidase and superoxide dismutase, known as major antioxidant enzymes, were reduced, compared to those in healthy controls. Levels of two other markers (mitofusin 2 and nuclear factor erythroid derived 2) also support hypotheses suggesting the involvement of oxidative stress in POP.
In the literature available, an association between oxidative stress and pelvic organ prolapse was confirmed.
盆腔器官脱垂（POP）的病理生理学尚未完全阐明，尽管越来越多的证据表明氧化应激与之相关。本系统综述全面讨论了这一主题。
检索了截至 2021 年 5 月的 PubMed/Medline、Scopus 和 Web of Science 数据库中相关研究。本系统综述已在 PROSPERO 数据库（注册号 CRD42021242240）中注册。两名独立研究人员筛选并选择符合预设纳入标准、进行质量评估和提取相关数据的文章。在 901 篇原始文章中，有 8 篇符合选择标准并被纳入综述。
在 POP 患者的盆底的各个部位发现了氧化应激标志物（如晚期糖基化终产物、羟壬烯醛和羟脱氧鸟苷）水平升高。相应地，与健康对照组相比，已知的主要抗氧化酶谷胱甘肽过氧化物酶和超氧化物歧化酶的水平降低。另外两种标志物（线粒体融合蛋白 2 和核因子红细胞衍生 2）的水平也支持了氧化应激参与 POP 的假设。
现有文献证实了氧化应激与盆腔器官脱垂之间的关联。
