Harada T, Kigure T, Miyagata S, Etori K, Kumazaki T, Koh D, Shimoda J, Nishizawa O, Matsuzaki A, Tsuchida S
Department of Urology, Akita University School of Medicine, Japan.
Urol Int. 1988;43(3):160-6. doi: 10.1159/000281330.
Twenty-five patients with transitional cell carcinoma of the bladder have been treated with combined therapy consisting of microwave regional coagulation and intracavitary irradiation. A remote-controlled after-loading system was utilized for the radiation therapy. The follow-up period ranged from 6 to 19 months with an average of 11.4 months. Tumor stages were Tis (n = 2), Ta or T1 (n = 17), T2 (n = 2), T3 (n = 3) and T4 (n = 1), and grades were G1 (n = 10), G2 (n = 11) and G3 (n = 4). In 23 patients (92%), there was no endoscopic or histologic evidence of tumor after the initial treatment. Heterotopic recurrences were found after 2 or 3 months in 3 patients who received microwave regional coagulation or intracavitary regional irradiation. Additional intracavitary whole bladder mucosal irradiation was performed for 10 patients with multiple tumors and frequent recurrent tumors. Nine patients had no recurrence (average follow-up 11 months). Our preliminary findings indicate that combination therapy of microwave coagulation and intracavitary irradiation is a useful treatment for bladder cancer.
25例膀胱移行细胞癌患者接受了微波区域凝固和腔内照射联合治疗。放射治疗采用遥控后装系统。随访时间为6至19个月，平均11.4个月。肿瘤分期为Tis（n = 2）、Ta或T1（n = 17）、T2（n = 2）、T3（n = 3）和T4（n = 1），分级为G1（n = 10）、G2（n = 11）和G3（n = 4）。23例患者（92%）在初始治疗后无肿瘤的内镜或组织学证据。3例接受微波区域凝固或腔内区域照射的患者在2或3个月后出现异位复发。对10例有多发性肿瘤和频繁复发肿瘤的患者进行了额外的腔内全膀胱黏膜照射。9例患者无复发（平均随访11个月）。我们的初步研究结果表明，微波凝固和腔内照射联合治疗是膀胱癌的一种有效治疗方法。
