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一例以心肺骤停为表现的嗜铬细胞瘤病例。

A case of pheochromocytoma presenting with cardiopulmonary arrest.

作者信息

Touma Takashi, Miyara Takafumi, Taba Yoji

机构信息

Department of Cardiology, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, Okinawa, Japan.

出版信息

J Cardiol Cases. 2019 Aug 29;20(6):225-227. doi: 10.1016/j.jccase.2019.08.009. eCollection 2019 Dec.

Abstract

A 33-year-old woman complained of sudden chest pain and intense headache. She was unconscious and underwent defibrillation for ventricular fibrillation in the ambulance. In the emergency room, she was placed on an artificial respirator. Diffuse wall hypokinesis and decreased left ventricular ejection fraction (31%) were identified on transthoracic echocardiography, and an intra-aortic balloon pump was inserted to address the cardiogenic shock. A mass was identified in the right adrenal gland on abdominal ultrasonography. Since a pheochromocytoma was suspected, doxazosin and carvedilol were administered. Blood and urinary norepinephrine and dopamine levels were elevated, confirming the pheochromocytoma diagnosis, and right adrenalectomy was performed 23 days after the initial hospitalization. After surgery, the left ventricular wall motion and left ventricular ejection fraction had improved to 62% on echocardiography. Blood and urinary norepinephrine and dopamine levels also decreased to within the normal range. This case highlights that the patient returned to normalcy and recovered to a transient myocardial disorder or malignant arrhythmia after cardiopulmonary arrest due to early diagnosis of and accurate treatment for pheochromocytoma. < Pheochromocytomas secrete excessive levels of catecholamines that may cause cardiac dysfunction, including fatal arrhythmias. It is necessary for the transient hypertension and fatal arrhythmia appearance to consider the possibility of pheochromocytoma. The decreased cardiac function may be reversible with resection of the tumor. Therefore, early diagnosis and treatment can be lifesaving in such cases. Pheochromocytomas provide an interesting model to evaluate the vulnerability of the myocardium to adrenergic stimulation, such as in cases of takotsubo cardiomyopathy or catecholamine-induced cardiomyopathy.>.

摘要

一名33岁女性主诉突发胸痛和剧烈头痛。她失去意识,在救护车上因心室颤动接受了除颤治疗。在急诊室,她被接上了人工呼吸机。经胸超声心动图显示弥漫性室壁运动减弱,左心室射血分数降低(31%),遂插入主动脉内球囊反搏以治疗心源性休克。腹部超声检查发现右肾上腺有一个肿块。由于怀疑是嗜铬细胞瘤,给予了多沙唑嗪和卡维地洛。血液和尿液中的去甲肾上腺素和多巴胺水平升高,证实了嗜铬细胞瘤的诊断,并在首次住院23天后进行了右肾上腺切除术。术后,超声心动图显示左心室壁运动和左心室射血分数改善至62%。血液和尿液中的去甲肾上腺素和多巴胺水平也降至正常范围。该病例表明,由于对嗜铬细胞瘤的早期诊断和准确治疗,患者在心肺骤停后恢复正常,从短暂性心肌疾病或恶性心律失常中康复。<嗜铬细胞瘤分泌过量儿茶酚胺,可能导致心脏功能障碍,包括致命性心律失常。对于短暂性高血压和致命性心律失常的出现,有必要考虑嗜铬细胞瘤的可能性。切除肿瘤后心脏功能下降可能是可逆的。因此,早期诊断和治疗在这类病例中可能挽救生命。嗜铬细胞瘤为评估心肌对肾上腺素能刺激的易损性提供了一个有趣的模型,如在应激性心肌病或儿茶酚胺诱导的心肌病病例中。>

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