Guei Monlet Cyr, Sidibé Marthe, Wognin Anastasie, Konan Serge Didier, Choho Motochi Carole, Yao Hubert Kouamé, Ackoundou-N'guessan Clément, Gnionsahé Appolinaire Daze
Service de Néphrologie, CHU de Yopougon, BP 632, Abidjan 21, Côte d'Ivoire.
Service de Néphrologie, CHU de Treichville, Kilomètre 1, Boulevard de Marseille, BP V 206, Abidjan, Côte d'Ivoire.
Pan Afr Med J. 2019 Sep 2;34:2. doi: 10.11604/pamj.2019.34.2.20016. eCollection 2019.
In Ivory Coast, the prevalence of human immunodeficiency virus (HIV) infection is high. Any organ can be affected, in particular the kidney. Some studies conducted in Ivory Coast highlighted that opportunistic infections are a poor prognostic factors for acute renal failure (ARF). The purpose of this study was to investigate the other possible factors associated with ARF outcome among subjects with HIV infection. We conducted a retrospective analytical study, at the University Hospital Center of Yopougon over the period January 2014-December 2017. All patients over the age of 18 years with HIV infection associated with ARF were enrolled. The study included 73 patients, reflecting a rate of 24%. The average age of patients was 39.32 ± 10.50 years, ranging from 18 to 65 years. Sex ratio of 1.6 favoured women. Obesity (p=0.047; OR=8.72; CI (95%)=1.07-39.21) and CD4 count < 200/mm (p=0.000; OR=58.50; IC (95%)=10.31-55.12) were associated with poor prognosis of ARF. In Ivory Coast, the hospital prevalence of ARF in patients with HIV is high. Unfavorable outcome included death or chronicity. In addition to deep immunosuppression already known as a poor prognostic factor, this study showed that obesity is associated with unfavorable outcome of ARF in subjects with HIV.
在科特迪瓦，人类免疫缺陷病毒（HIV）感染的患病率很高。任何器官都可能受到影响，尤其是肾脏。在科特迪瓦进行的一些研究强调，机会性感染是急性肾衰竭（ARF）的不良预后因素。本研究的目的是调查HIV感染患者中与ARF预后相关的其他可能因素。我们于2014年1月至2017年12月在约普贡大学医院中心进行了一项回顾性分析研究。纳入所有18岁以上合并ARF的HIV感染患者。该研究包括73名患者，占比24%。患者的平均年龄为39.32±10.50岁，年龄范围为18至65岁。性别比为1.6，女性占优。肥胖（p=0.047；OR=8.72；CI（95%）=1.07 - 39.21）和CD4计数<200/mm³（p=0.000；OR=58.50；IC（95%）=10.31 - 55.12）与ARF的不良预后相关。在科特迪瓦，HIV患者中ARF的医院患病率很高。不良结局包括死亡或慢性化。除了已知的深度免疫抑制作为不良预后因素外，本研究表明肥胖与HIV感染患者ARF的不良结局相关。
