Ndikuwera J, Winstanley E W, Binta-Mushi G, Mushi E Z
Faculty of Veterinary Science, University of Zimbabwe, Harare.
Vet Res Commun. 1988;12(1):77-86. doi: 10.1007/BF00396406.
Povidone-iodine caused peritonitis with neutrophilic leukocytosis and a minimal left shift at the dosage rate of 3.5 ml/kg body weight. A dosage rate of 2 ml/kg only caused slight neutrophilic leukocytosis. There was a significant increase in the levels of creatinine (p = 0.049) and BUN (p = 0.020) in dogs that received the higher dose rate. Two dogs died from povidone-iodine toxicity with a marked increase in ALT, AP, SDH and conjugated bilirubin. It is concluded that povidone-iodine is unsafe for use in the peritoneal cavity of dogs.
聚乙烯吡咯烷酮碘以3.5毫升/千克体重的剂量率给药时，可引发腹膜炎，伴有嗜中性白细胞增多症，且左移现象轻微。2毫升/千克的剂量率仅引起轻微的嗜中性白细胞增多。接受较高剂量率的犬只，其肌酐水平（p = 0.049）和血尿素氮水平（p = 0.020）显著升高。两只犬死于聚乙烯吡咯烷酮碘中毒，谷丙转氨酶、碱性磷酸酶、山梨醇脱氢酶和结合胆红素显著升高。结论是，聚乙烯吡咯烷酮碘用于犬的腹腔是不安全的。
