McAvinchey D J, McCollum P T, McElearney N G, Mundinger G, Lynch G
Br J Surg. 1983 Mar;70(3):158-60. doi: 10.1002/bjs.1800700307.
A controlled mixed peritoneal infection was produced by inoculation of bacteria into the peritoneum and peritonitis was allowed to become established. A laparotomy was performed and peritoneal toilet with a variety of agents was carried out. Local povidone-iodine in the inflamed peritoneum proved to be not only of no benefit but, in fact, to be toxic. In the standard concentrations recommended it proved lethal. Noxythiolin 2.5 per cent also had no beneficial effect. There was a significant difference between the effect of povidone-iodine when instilled into an inflamed peritoneum and instillation into the intact peritoneal cavity. We would advise caution in the use of these antiseptics in any situation in which local defence mechanisms have been compromised as a result of established infection.
通过将细菌接种到腹膜中来制造可控的混合性腹膜感染，使腹膜炎得以形成。进行剖腹手术，并使用多种药剂进行腹膜清洗。事实证明，发炎腹膜中的局部聚维酮碘不仅没有益处，反而具有毒性。在推荐的标准浓度下，它被证明是致命的。2.5%的硝噻唑啉也没有有益效果。将聚维酮碘注入发炎腹膜与注入完整腹膜腔的效果之间存在显著差异。我们建议，在因已确立的感染而导致局部防御机制受损的任何情况下，谨慎使用这些防腐剂。
