Shao De-Rong, Zhou Yue
Department of Nephrology.
Department of Endocrinology, The Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang, China.
Medicine (Baltimore). 2019 Nov;98(47):e17923. doi: 10.1097/MD.0000000000017923.
This study aims to assess the efficacy and safety of dialysis for the treatment of patients with diabetic nephropathy (DN).
We will comprehensively retrieve the following databases of Cochrane Library, PUBMED, EMBASE, Global health, CINAHL, PsycINFO, Scopus, CBM, Wangfang, and CNKI for studies related to the topic. We will search all those electronic databases from their inceptions to the present without restrictions of language and publication status. Two authors will independently conduct all procedures of study selection, data collection, and risk of bias assessment. We will apply RevMan 5.3 software for statistical analysis.
We will systematically investigate the efficacy and safety of dialysis for DN through assessing primary and secondary outcomes. The primary outcomes include improvement in renal function, as assessed by the urinary albumin/creatinine ratio, estimated glomerular filtration rate, and serum creatinine levels. The secondary outcomes consist of levels of inflammatory markers, endothelial dysfunction markers, quality of life, and any expected and unexpected adverse events.
This study will present evidence on the efficacy and safety of dialysis for the treatment of patients with DN.
PROSPERO CRD42019149699.
本研究旨在评估透析治疗糖尿病肾病（DN）患者的疗效和安全性。
我们将全面检索Cochrane图书馆、PUBMED、EMBASE、全球卫生、CINAHL、PsycINFO、Scopus、中国生物医学文献数据库、万方数据库和中国知网等数据库中与该主题相关的研究。我们将检索所有这些电子数据库，从其创建至今，不受语言和出版状态的限制。两位作者将独立进行研究选择、数据收集和偏倚风险评估的所有程序。我们将应用RevMan 5.3软件进行统计分析。
我们将通过评估主要和次要结局，系统地研究透析治疗DN的疗效和安全性。主要结局包括通过尿白蛋白/肌酐比值、估计肾小球滤过率和血清肌酐水平评估的肾功能改善情况。次要结局包括炎症标志物水平、内皮功能障碍标志物、生活质量以及任何预期和意外的不良事件。
本研究将提供关于透析治疗DN患者疗效和安全性的证据。
PROSPERO CRD42019149699。
