Department of Physics, Institute for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, 5290002, Israel.
Institute for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, 5290002, Israel.
Small. 2019 Dec;15(52):e1903006. doi: 10.1002/smll.201903006. Epub 2019 Nov 25.
Integral membrane proteins mediate a myriad of cellular processes and are the target of many therapeutic drugs. Enhancement and extension of the functional scope of membrane proteins can be realized by membrane incorporation of engineered nanoparticles designed for specific diagnostic and therapeutic applications. In contrast to hydrophobic insertion of small amphiphilic molecules, delivery and membrane incorporation of particles on the nanometric scale poses a crucial barrier for technological development. In this perspective, the transformative potential of biomimetic membrane proteins (BMPs), current state of the art, and the barriers that need to be overcome in order to advance the field are discussed.
整合膜蛋白介导着众多的细胞过程，也是许多治疗药物的靶点。通过将专门设计用于特定诊断和治疗应用的工程纳米颗粒整合到膜中，可以增强和扩展膜蛋白的功能范围。与疏水性插入小两亲分子不同，纳米级颗粒的传递和膜整合对技术发展构成了关键障碍。在这篇观点文章中，讨论了仿生膜蛋白 (BMPs) 的变革潜力、当前的最新技术，以及为推进该领域需要克服的障碍。
