School of Laboratory Medicine and Medical Sciences (SLMMS), College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; Department of Health Sciences, Faculty of Health and Applied Sciences, Namibia University of Science and Technology, Windhoek, Namibia.
Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy; Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, South Africa.
Clin Immunol. 2020 Jan;210:108313. doi: 10.1016/j.clim.2019.108313. Epub 2019 Nov 22.
Chronic immune activation has been described in the development of cardiovascular diseases (CVDs) and in the pathogenesis of type 2 diabetes mellitus (T2D). However, the precise functional role of T-cells remains controversial. We therefore, assessed T-cell activation and cardiovascular risk in T2D.
The protocol was registered with PROSPERO [CRD42018099745]. We searched electronic databases and grey literature for eligible studies. The risk of bias and quality of evidence were assessed and the random-effects model was used in the meta-analysis.
Fifteen studies met the inclusion criteria. We report on increased T-cell activation in T2D and nondiabetics with CVD. Comorbidity of T2D and CVD (T2D + CVD) exacerbated T-cell activation. In addition, T2D + CVD comorbidity was associated with an increased CVD risk profile.
This meta-analysis suggests increased T-cell activation in T2D and nondiabetics with CVD. Moreover, an increased cardiovascular risk in patients with T2D which is exacerbated in T2D and CVD comorbidity.
慢性免疫激活已在心血管疾病 (CVD) 的发展和 2 型糖尿病 (T2D) 的发病机制中被描述。然而，T 细胞的确切功能作用仍存在争议。因此，我们评估了 T 细胞激活与 T2D 的心血管风险。
该方案已在 PROSPERO [CRD42018099745] 中注册。我们在电子数据库和灰色文献中搜索符合条件的研究。评估了偏倚风险和证据质量，并在荟萃分析中使用了随机效应模型。
符合纳入标准的有 15 项研究。我们报告了 T2D 和患有 CVD 的非糖尿病患者中 T 细胞激活增加。T2D 和 CVD 的合并症 (T2D+CVD) 加重了 T 细胞激活。此外，T2D+CVD 合并症与增加的心血管风险特征相关。
这项荟萃分析表明，T2D 和患有 CVD 的非糖尿病患者中 T 细胞激活增加。此外，T2D 患者的心血管风险增加，在 T2D 和 CVD 合并症中更为严重。
