Podczeck A, Floren J, Borggrefe M, Breithardt G
Medizinische Universitätsklinik und Poliklinik, Abteilung Innere Medizin C, Westfälischen Wilhelms-Universität Münster.
Z Kardiol. 1988 Aug;77(8):515-22.
To get some insight into the clinical profile of patients with ventricular tachyarrhythmias and to elucidate potential time-dependent changes, data from 421 patients with documented tachyarrhythmias referred for electrophysiologic studies, were analyzed. The observation period is extended from 1978 to 1986. Patient's data were analyzed in 2-year subperiods. There were no major changes with regard to underlying heart disease, or within the interval between myocardial infarction and electrophysiologic study, or with regard to the indication for electrophysiologic study and the results of right ventricular stimulation during the analyzed subperiods. The interval between the first episode of documented tachyarrhythmia and the study, as well as the number of previous episodes of documented arrhythmias, decreased significantly between the first observation period (1978/79) and all the following periods. Before 1982, about 2% of patients were on amiodarone therapy at the time of referral, whereas from 1982 a higher proportion of cases was referred on amiodarone (21%, 12%, resp.). Over the whole observation period, an increasing number of patients finally underwent antitachycardia surgery.
为深入了解室性快速心律失常患者的临床特征，并阐明潜在的时间依赖性变化，我们分析了421例因电生理研究而转诊的有记录的快速心律失常患者的数据。观察期从1978年延长至1986年。患者数据按2年的子周期进行分析。在分析的子周期内，潜在心脏病、心肌梗死与电生理研究之间的间隔、电生理研究的指征以及右心室刺激的结果均无重大变化。记录的快速心律失常首次发作与研究之间的间隔，以及既往记录的心律失常发作次数，在第一个观察期（1978/79年）与随后所有时期之间均显著减少。1982年之前，约2%的患者在转诊时接受胺碘酮治疗，而从1982年起，转诊时接受胺碘酮治疗的病例比例更高（分别为21%、12%）。在整个观察期内，最终接受抗心动过速手术的患者数量不断增加。
