Santus Pierachille, Radovanovic Dejan, Chiumello Davide Alberto
Department of Biomedical and Clinical Sciences (DIBIC), Division of Respiratory Diseases, Università degli Studi di Milano, Ospedale L. Sacco, ASST Fatebenfratelli-Sacco, Via G.B. Grassi, 74-20157 Milano, Italy.
SC Anestesia e Rianimazione, Ospedale San Paolo-Polo Universitario, ASST Santi Paolo e Carlo, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Via Antonio di Rudinì, 8-20142 Milano, Italy.
J Clin Med. 2019 Nov 13;8(11):1955. doi: 10.3390/jcm8111955.
Mucus represents the first line of defense of our respiratory tract and mucociliary clearance is essential for maintaining the homeostasis of airway epithelium. The latter mechanisms are altered in asthma and mucus plugging of proximal and distal airways is the main cause of death in cases of fatal asthma. Starting from the influential review performed by Luke R. Bonser and David J. Erle in 2017, we discuss the latest evidence in terms of mucins regulation and potential treatment of mucus hypersecretion and tissue remodeling in severe asthma.
黏液是我们呼吸道的第一道防线，黏液纤毛清除功能对于维持气道上皮的稳态至关重要。在哮喘中，后一种机制会发生改变，近端和远端气道的黏液阻塞是致死性哮喘病例死亡的主要原因。从卢克·R·邦泽和大卫·J·厄尔于2017年发表的有影响力的综述出发，我们讨论了黏蛋白调节以及重度哮喘中黏液高分泌和组织重塑的潜在治疗方面的最新证据。
