Aynsley-Green A
Department of Child Health, University of Newcastle upon Tyne, Medical School, Great Britain.
Z Kinderchir. 1988 Aug;43(4):267-72. doi: 10.1055/s-2008-1043468.
An analysis of 33 cases of children suffering from hyper-insulinism as a result of islet cell dysregulation is presented. Twenty-two children presented in the first 3 days after birth with the classical symptoms of hypoglycaemia. A second peak appeared between the ages of 4 months and 2 years after birth, hyperinsulinism becoming increasingly uncommon with advancing age. A logical approach to the diagnosis is presented based on an understanding of the metabolic effects of hyperinsulinism in causing hypoketonaemic hypo-fattyacidaemic hypoglycaemia. An analysis of the management of these cases is also presented It is concluded that the diagnosis of hyperinsulinism in infancy and childhood is relatively easy to make, and that a careful and logical plan of management should prevent the high incidence of neurological damage which has been reported previously in survivors.
本文对33例因胰岛细胞调节异常而患高胰岛素血症的儿童病例进行了分析。22名儿童在出生后的头3天出现了低血糖的典型症状。第二个高峰出现在出生后4个月至2岁之间，随着年龄的增长，高胰岛素血症越来越少见。基于对高胰岛素血症导致低酮血症、低脂血症性低血糖的代谢影响的理解，提出了一种合理的诊断方法。本文还对这些病例的治疗进行了分析。结论是，婴儿期和儿童期高胰岛素血症的诊断相对容易做出，并且精心合理的治疗方案应能预防先前报道的幸存者中较高的神经损伤发生率。
