Predictors of Mortality in Bloodstream Infections Caused by Pseudomonas aeruginosa and Impact of Antimicrobial Resistance and Bacterial Virulence.

Whether multidrug resistance (MDR) is associated with mortality in patients with bloodstream infections (BSI) remains controversial. Here, we explored the prognostic factors of BSI with emphasis on antimicrobial resistance and virulence. All BSI episodes in a 5-year period were retrospectively analyzed. The impact in early (5-day) and late (30-day) crude mortality of host, antibiotic treatment, and pathogen factors was assessed by multivariate logistic regression analysis. Of 243 episodes, 93 (38.3%) were caused by MDR-PA. Crude 5-day (20%) and 30-day (33%) mortality was more frequent in patients with MDR-PA (34.4% versus 11.3%, < 0.001 and 52.7% versus 21.3%, < 0.001, respectively). Early mortality was associated with neutropenia (adjusted odds ratio [aOR], 9.21; 95% confidence interval [CI], 3.40 to 24.9; < 0.001), increased Pitt score (aOR, 2.42; 95% CI, 1.34 to 4.36; = 0.003), respiratory source (aOR, 3.23; 95% CI,2.01 to 5.16; < 0.001), inadequate empirical therapy (aOR, 4.57; 95% CI, 1.59 to 13.1; = 0.005), shorter time to positivity of blood culture (aOR, 0.88; 95% CI, 0.80 to 0.97; = 0.010), an -positive genotype (aOR, 3.58; 95% CI, 1.31 to 9.79; = 0.013), and the O11 serotype (aOR, 3.64; 95% CI, 1.20 to 11.1; = 0.022). These risk factors were similarly identified for late mortality, along with an MDR phenotype (aOR, 2.18; 95% CI, 1.04 to 4.58; = 0.040). Moreover, the O11 serotype (15.2%, 37/243) was common among MDR (78.4%, 29/37) and -positive (89.2%, 33/37) strains. Besides relevant clinical variables and inadequate empirical therapy, pathogen-related factors such as an MDR phenotype, an -positive genotype, and the O11 serotype adversely affect the outcome of BSI.