杏仁核中的巴甫洛夫模式。
Pavlovian patterns in the amygdala.
机构信息
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
Nat Neurosci. 2019 Dec;22(12):1949-1950. doi: 10.1038/s41593-019-0543-8.
Abstract
Reitich-Stolero and Paz examined multi-neuron correlates of Pavlovian learning in the primate amygdala. They found repeating patterns of activity across neurons that may mediate synaptic level plasticity mechanisms. This extends the notion of replay, often examined relative to navigation in the hippocampus, to aversive learning in the amygdala.
摘要
赖蒂奇-斯托勒罗和帕兹研究了灵长类动物杏仁核中与巴甫洛夫式学习相关的多神经元关联。他们发现神经元活动中存在重复模式，这可能介导了突触水平的可塑性机制。这一发现将回放的概念扩展到了杏仁核的厌恶学习，而回放通常是相对于海马体中的导航来研究的。
相似文献
1
Pavlovian patterns in the amygdala.杏仁核中的巴甫洛夫模式。
Nat Neurosci. 2019 Dec;22(12):1949-1950. doi: 10.1038/s41593-019-0543-8.
2
Pavlovian fear conditioning activates a common pattern of neurons in the lateral amygdala of individual brains.巴甫洛夫式恐惧条件反射激活了个体大脑外侧杏仁核中神经元的一种常见模式。
PLoS One. 2011 Jan 12;6(1):e15698. doi: 10.1371/journal.pone.0015698.
3
The structure of Pavlovian fear conditioning in the amygdala.杏仁核中条件性恐惧反应的结构。
Brain Struct Funct. 2013 Nov;218(6):1569-89. doi: 10.1007/s00429-012-0478-2. Epub 2012 Nov 20.
4
A pavlovian model of the amygdala and its influence within the medial temporal lobe.杏仁核的巴甫洛夫模型及其在内侧颞叶中的影响。
Front Syst Neurosci. 2015 Mar 18;9:41. doi: 10.3389/fnsys.2015.00041. eCollection 2015.
5
Differential role of Rac in the basolateral amygdala and cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats.Rac在大鼠基底外侧杏仁核和海马1区在听觉和情境性巴甫洛夫恐惧记忆再巩固中的不同作用。
Psychopharmacology (Berl). 2014 Aug;231(15):2909-19. doi: 10.1007/s00213-014-3462-0. Epub 2014 Feb 20.
6
Neuronal signalling of fear memory.恐惧记忆的神经元信号传导
Nat Rev Neurosci. 2004 Nov;5(11):844-52. doi: 10.1038/nrn1535.
7
An organization of visual and auditory fear conditioning in the lateral amygdala.外侧杏仁核中视觉和听觉恐惧条件反射的组织形式。
Neurobiol Learn Mem. 2014 Dec;116:1-13. doi: 10.1016/j.nlm.2014.07.008. Epub 2014 Jul 27.
8
Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning.杏仁核中ERK/MAP激酶的激活是巴甫洛夫恐惧条件反射记忆巩固所必需的。
J Neurosci. 2000 Nov 1;20(21):8177-87. doi: 10.1523/JNEUROSCI.20-21-08177.2000.
9
Mechanisms contributing to the induction and storage of Pavlovian fear memories in the lateral amygdala.在外侧杏仁核中诱导和储存巴甫洛夫恐惧记忆的机制。
Learn Mem. 2013 Jul 17;20(8):421-30. doi: 10.1101/lm.030262.113.
10
Mice selectively bred for High and Low fear behavior show differences in the number of pMAPK (p44/42 ERK) expressing neurons in lateral amygdala following Pavlovian fear conditioning.经过选择性培育的具有高恐惧行为和低恐惧行为的小鼠，在经典条件恐惧训练后，外侧杏仁核中表达磷酸化丝裂原活化蛋白激酶（p44/42 细胞外信号调节激酶）的神经元数量存在差异。
Neurobiol Learn Mem. 2014 Jul;112:195-203. doi: 10.1016/j.nlm.2013.06.010. Epub 2013 Jun 28.
引用本文的文献
1
Hypothalamic Interactions with Large-Scale Neural Circuits Underlying Reinforcement Learning and Motivated Behavior.下丘脑与强化学习和动机行为相关的大规模神经回路的相互作用。
Trends Neurosci. 2020 Sep;43(9):681-694. doi: 10.1016/j.tins.2020.06.006. Epub 2020 Aug 3.
本文引用的文献
1
Affective memory rehearsal with temporal sequences in amygdala neurons.杏仁核神经元中具有时间序列的情感记忆排练。
Nat Neurosci. 2019 Dec;22(12):2050-2059. doi: 10.1038/s41593-019-0542-9. Epub 2019 Nov 25.
2
Motivational neural circuits underlying reinforcement learning.强化学习的动机神经回路。
Nat Neurosci. 2017 Mar 29;20(4):505-512. doi: 10.1038/nn.4506.
3
Using model systems to understand errant plasticity mechanisms in psychiatric disorders.利用模型系统来理解精神疾病中异常的可塑性机制。
Nat Neurosci. 2016 Nov;19(11):1418-1425. doi: 10.1038/nn.4413. Epub 2016 Oct 26.
4
Postmortem examination of patient H.M.'s brain based on histological sectioning and digital 3D reconstruction.基于组织切片和数字三维重建对患者H.M.的大脑进行尸检。
Nat Commun. 2014;5:3122. doi: 10.1038/ncomms4122.
5
Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval.清醒状态下的海马体回放：记忆巩固和提取的潜在基础。
Nat Neurosci. 2011 Feb;14(2):147-53. doi: 10.1038/nn.2732.
6
Stochastic emergence of repeating cortical motifs in spontaneous membrane potential fluctuations in vivo.体内自发膜电位波动中重复皮质基序的随机出现。
Neuron. 2007 Feb 1;53(3):413-25. doi: 10.1016/j.neuron.2007.01.017.
7
Synfire chains and cortical songs: temporal modules of cortical activity.同步激发链与皮层之歌：皮层活动的时间模块
Science. 2004 Apr 23;304(5670):559-64. doi: 10.1126/science.1093173.
8
Multineuronal firing patterns in the signal from eye to brain.从眼睛到大脑的信号中的多神经元放电模式。
Neuron. 2003 Feb 6;37(3):499-511. doi: 10.1016/s0896-6273(03)00004-7.
9
Ibotenate Lesions of Hippocampus and/or Subiculum: Dissociating Components of Allocentric Spatial Learning.海马体和/或下托的异搏定损伤：分离以自我为中心的空间学习的组成部分。
Eur J Neurosci. 1990;2(12):1016-1028. doi: 10.1111/j.1460-9568.1990.tb00014.x.
10
Retinal ganglion cells act largely as independent encoders.视网膜神经节细胞在很大程度上起着独立编码器的作用。
Nature. 2001 Jun 7;411(6838):698-701. doi: 10.1038/35079612.
Zotero 插件