Huda Tanweerul, Singh Mahendra Pratap
Department of General Surgery, All India Institute of Medical Sciences, Bhopal, India.
Gastrointest Tumors. 2019 Oct;6(3-4):116-121. doi: 10.1159/000501744. Epub 2019 Aug 20.
Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract arising from interstitial Cajal cells. A 54-year-old male patient without any comorbidities presented to the emergency department with complaints of abdominal distension, inability to pass flatus, and no motion for the past 2 days. Abdominal X-ray showed multiple air-fluid levels suggesting bowel obstruction. The patient was managed conservatively at first. Later, ultrasonography and contrast-enhanced computed tomography (CECT) of the abdomen were done, which revealed a mass lesion arising from the jejunum suggestive of GIST. The patient was taken up for exploratory laparotomy, and a tumor was found in the proximal jejunum around 10 cm from the duodenojejunal junction and encompassing the hepatic flexure of the transverse colon, with the omentum found adhered to the anterior surface of the lesion and distended proximal bowel loops. There was no evidence of mesenteric lymphadenopathy. The mass was resected along with the jejunal loop and the hepatic flexure of the colon, followed by end-to-end jejunojejunal anastomosis and end-to-end colocolic anastomosis. The patient's postoperative stay was uneventful. Imatinib therapy was started following histopathological confirmation and continued. The patient was followed up for 1 year postoperatively with CECT of the abdomen every 6 months, with no evidence of recurrence or any gastro-intestinal symptoms.
胃肠道间质瘤(GISTs)是起源于间质 Cajal 细胞的胃肠道间叶性肿瘤。一名 54 岁无任何合并症的男性患者因腹胀、无法排气及近 2 天无排便就诊于急诊科。腹部 X 线显示多个气液平面,提示肠梗阻。患者最初接受保守治疗。之后,进行了腹部超声和增强计算机断层扫描(CECT),结果显示空肠有一肿块病变,提示为 GIST。患者接受了剖腹探查术,在距十二指肠空肠交界处约 10 cm 的空肠近端发现一个肿瘤,该肿瘤累及横结肠肝曲,大网膜附着于病变前表面,近端肠袢扩张。无肠系膜淋巴结肿大证据。将肿块连同空肠袢和结肠肝曲一并切除,随后进行空肠端端吻合和结肠端端吻合。患者术后恢复顺利。经组织病理学确诊后开始伊马替尼治疗并持续用药。术后对患者进行了 1 年随访,每 6 个月进行一次腹部 CECT,无复发迹象及任何胃肠道症状。