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本文引用的文献

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Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up.胃肠道间质瘤:ESMO-EURACAN诊断、治疗及随访临床实践指南
Ann Oncol. 2018 Oct 1;29(Suppl 4):iv267. doi: 10.1093/annonc/mdy320.
2
Gastrointestinal stromal tumors of the stomach in children and young adults: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases with long-term follow-up and review of the literature.儿童和青年成人胃胃肠道间质瘤:44例临床病理、免疫组化及分子遗传学研究并长期随访及文献复习
Am J Surg Pathol. 2005 Oct;29(10):1373-81. doi: 10.1097/01.pas.0000172190.79552.8b.
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Diagnosis of gastrointestinal stromal tumors: A consensus approach.胃肠道间质瘤的诊断:一种共识方法。
Hum Pathol. 2002 May;33(5):459-65. doi: 10.1053/hupa.2002.123545.
4
Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: a clinicopathologic, immunohistochemical, and molecular genetic study of 144 cases.直肠和肛门的胃肠道间质瘤、壁内平滑肌瘤及平滑肌肉瘤:144例临床病理、免疫组化及分子遗传学研究
Am J Surg Pathol. 2001 Sep;25(9):1121-33. doi: 10.1097/00000478-200109000-00002.
5
Gastrointestinal stromal tumors and leiomyosarcomas in the colon: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases.结肠胃肠道间质瘤和平滑肌肉瘤:44例临床病理、免疫组织化学及分子遗传学研究
Am J Surg Pathol. 2000 Oct;24(10):1339-52. doi: 10.1097/00000478-200010000-00003.
6
Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome.胃肠道外(软组织)间质瘤:48例病例分析,重点关注预后的组织学预测指标。
Mod Pathol. 2000 May;13(5):577-85. doi: 10.1038/modpathol.3880099.
7
A clinicopathologic and immunohistochemical study of gastrointestinal stromal tumors.胃肠道间质瘤的临床病理及免疫组织化学研究
Cancer. 1992 Feb 15;69(4):947-55. doi: 10.1002/1097-0142(19920215)69:4<947::aid-cncr2820690419>3.0.co;2-x.

以肠梗阻为表现的空肠巨大胃肠道间质瘤:一种罕见的表现。

Huge Gastrointestinal Stromal Tumor of the Jejunum Presenting as Bowel Obstruction: A Rare Presentation.

作者信息

Huda Tanweerul, Singh Mahendra Pratap

机构信息

Department of General Surgery, All India Institute of Medical Sciences, Bhopal, India.

出版信息

Gastrointest Tumors. 2019 Oct;6(3-4):116-121. doi: 10.1159/000501744. Epub 2019 Aug 20.

DOI:10.1159/000501744
PMID:31768355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6872987/
Abstract

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract arising from interstitial Cajal cells. A 54-year-old male patient without any comorbidities presented to the emergency department with complaints of abdominal distension, inability to pass flatus, and no motion for the past 2 days. Abdominal X-ray showed multiple air-fluid levels suggesting bowel obstruction. The patient was managed conservatively at first. Later, ultrasonography and contrast-enhanced computed tomography (CECT) of the abdomen were done, which revealed a mass lesion arising from the jejunum suggestive of GIST. The patient was taken up for exploratory laparotomy, and a tumor was found in the proximal jejunum around 10 cm from the duodenojejunal junction and encompassing the hepatic flexure of the transverse colon, with the omentum found adhered to the anterior surface of the lesion and distended proximal bowel loops. There was no evidence of mesenteric lymphadenopathy. The mass was resected along with the jejunal loop and the hepatic flexure of the colon, followed by end-to-end jejunojejunal anastomosis and end-to-end colocolic anastomosis. The patient's postoperative stay was uneventful. Imatinib therapy was started following histopathological confirmation and continued. The patient was followed up for 1 year postoperatively with CECT of the abdomen every 6 months, with no evidence of recurrence or any gastro-intestinal symptoms.

摘要

胃肠道间质瘤(GISTs)是起源于间质 Cajal 细胞的胃肠道间叶性肿瘤。一名 54 岁无任何合并症的男性患者因腹胀、无法排气及近 2 天无排便就诊于急诊科。腹部 X 线显示多个气液平面,提示肠梗阻。患者最初接受保守治疗。之后,进行了腹部超声和增强计算机断层扫描(CECT),结果显示空肠有一肿块病变,提示为 GIST。患者接受了剖腹探查术,在距十二指肠空肠交界处约 10 cm 的空肠近端发现一个肿瘤,该肿瘤累及横结肠肝曲,大网膜附着于病变前表面,近端肠袢扩张。无肠系膜淋巴结肿大证据。将肿块连同空肠袢和结肠肝曲一并切除,随后进行空肠端端吻合和结肠端端吻合。患者术后恢复顺利。经组织病理学确诊后开始伊马替尼治疗并持续用药。术后对患者进行了 1 年随访,每 6 个月进行一次腹部 CECT,无复发迹象及任何胃肠道症状。