• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

空肠胃肠道间质瘤穿孔致急腹症:一例报告

Acute abdomen due to perforated jejunal gastrointestinal stromal tumor: A case report.

作者信息

Dev Santosh, Luitel Prajjwol, Paudel Sujan, Shrestha Asim, Dev Barsha, Sah Jayant

机构信息

Department of General Surgery, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Nepal.

Department of General Surgery, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Nepal; Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Nepal.

出版信息

Int J Surg Case Rep. 2024 Aug;121:109922. doi: 10.1016/j.ijscr.2024.109922. Epub 2024 Jun 21.

DOI:10.1016/j.ijscr.2024.109922
PMID:38908159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11637173/
Abstract

INTRODUCTION

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors, with jejunal GISTs being particularly uncommon. Jejunal GISTs causing perforation and acute diffuse peritonitis is rare.

CASE PRESENTATION

A 53-year-old female with a history of hypertension presented with severe, acute abdominal pain and vomiting. Examination revealed abdominal distension, tenderness, and guarding, with imaging suggestive of gastrointestinal perforation. Emergency laparotomy revealed a 9 cm × 8 cm mass with perforation in the jejunum, which was resected which on histopathological examination confirmed a low-grade GIST. The postoperative course was complicated by a wound infection, managed with antibiotics and secondary suturing. At one-year follow-up, the patient remained disease-free without the need for adjuvant therapy.

CLINICAL DISCUSSION

The most common symptoms of jejunal GISTs include vague abdominal pain or discomfort, early satiety, obstruction or hemorrhage. Preoperative diagnosis and confirmation of GIST is difficult due to nonspecific symptoms and none of the radiographic procedures can establish the diagnosis with certainty. The surgical excision of the tumor along with infiltrated tissues is the treatment of choice for GIST.

CONCLUSION

This case underscores the necessity of considering GISTs in differential diagnoses of acute abdomen and the critical role of prompt surgical management and multidisciplinary care in achieving favorable outcomes.

摘要

引言

胃肠道间质瘤(GISTs)是罕见的间叶组织肿瘤,空肠GISTs尤其少见。导致穿孔和急性弥漫性腹膜炎的空肠GISTs很罕见。

病例介绍

一名有高血压病史的53岁女性,出现严重的急性腹痛和呕吐。检查发现腹胀、压痛和肌紧张,影像学检查提示胃肠道穿孔。急诊剖腹探查发现空肠有一个9厘米×8厘米的肿块并伴有穿孔,予以切除,组织病理学检查证实为低级别GIST。术后病程因伤口感染而复杂化,通过抗生素治疗和二次缝合处理。在一年的随访中,患者无疾病复发,无需辅助治疗。

临床讨论

空肠GISTs最常见的症状包括腹部隐痛或不适、早饱、梗阻或出血。由于症状不具特异性,术前诊断和确诊GIST很困难,且没有任何影像学检查能确定诊断。手术切除肿瘤及受累组织是GIST的首选治疗方法。

结论

该病例强调了在急腹症鉴别诊断中考虑GISTs的必要性,以及及时手术治疗和多学科护理在取得良好预后方面的关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a8/11637173/5fefa7e46df5/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a8/11637173/be11a1e21242/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a8/11637173/f0ffa94aa7f9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a8/11637173/1f5ca1eefb41/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a8/11637173/68aa3ae717dc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a8/11637173/5fefa7e46df5/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a8/11637173/be11a1e21242/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a8/11637173/f0ffa94aa7f9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a8/11637173/1f5ca1eefb41/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a8/11637173/68aa3ae717dc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a8/11637173/5fefa7e46df5/gr5.jpg

相似文献

1
Acute abdomen due to perforated jejunal gastrointestinal stromal tumor: A case report.空肠胃肠道间质瘤穿孔致急腹症:一例报告
Int J Surg Case Rep. 2024 Aug;121:109922. doi: 10.1016/j.ijscr.2024.109922. Epub 2024 Jun 21.
2
Acute abdomen due to a perforated giant GIST of the small intestine evolving slowly for 6 years: A case report.小肠巨大胃肠道间质瘤穿孔导致的急性腹痛,病程6年缓慢进展:一例报告
Int J Surg Case Rep. 2025 Apr;129:111207. doi: 10.1016/j.ijscr.2025.111207. Epub 2025 Mar 25.
3
Peritonitis secondary to spontaneous perforation of a primary gastrointestinal stromal tumour of the small intestine: A case report and a literature review.小肠原发性胃肠道间质瘤自发性穿孔继发腹膜炎:一例报告及文献复习
Int J Surg Case Rep. 2015;6C:58-62. doi: 10.1016/j.ijscr.2014.12.012. Epub 2014 Dec 12.
4
Perforated proximal jejunal gastrointestinal stromal tumor pT4N0M0 presenting with severe sepsis: A case report and literature review.以严重脓毒症为表现的穿孔性近端空肠胃肠道间质瘤pT4N0M0:病例报告及文献复习
Ann Med Surg (Lond). 2020 Jul 20;57:76-81. doi: 10.1016/j.amsu.2020.07.024. eCollection 2020 Sep.
5
Spontaneous perforation of jejunal gastrointestinal stromal tumor: A case report.空肠胃肠道间质瘤自发性穿孔:一例报告
Int J Surg Case Rep. 2020;73:31-34. doi: 10.1016/j.ijscr.2020.06.088. Epub 2020 Jun 27.
6
A case report: Peritonitis secondary to perforated locally advanced gastrointestinal stromal tumor.病例报告:局部晚期胃肠道间质瘤穿孔继发腹膜炎
Int J Surg Case Rep. 2024 Jun;119:109739. doi: 10.1016/j.ijscr.2024.109739. Epub 2024 May 9.
7
Acute diffuse peritonitis due to spontaneous rupture of a primary gastrointestinal stromal tumor of the jejunum: A case report.空肠原发性胃肠道间质瘤自发性破裂导致急性弥漫性腹膜炎:一例报告
Int J Surg Case Rep. 2017;39:288-292. doi: 10.1016/j.ijscr.2017.08.041. Epub 2017 Aug 23.
8
Jejunal diverticulitis secondary to a gastrointestinal stromal tumor: A case report.胃肠道间质瘤继发空肠憩室炎:一例报告。
Int J Surg Case Rep. 2021 Aug;85:106291. doi: 10.1016/j.ijscr.2021.106291. Epub 2021 Aug 8.
9
Perforated gastrointestinal stromal tumor (GIST) in a true jejunal diverticulum in adulthood: report of a case.成人真性空肠憩室中的穿孔性胃肠道间质瘤(GIST):一例报告。
Surg Today. 2014 Nov;44(11):2180-6. doi: 10.1007/s00595-013-0732-0. Epub 2013 Sep 20.
10
Unusual case report of bifocal gastrointestinal stromal tumor in the first jejunal loop uncovered by severe hemorrhage.首例空肠袢双灶性胃肠道间质瘤伴严重出血的罕见病例报告
Int J Surg Case Rep. 2024 Nov;124:110334. doi: 10.1016/j.ijscr.2024.110334. Epub 2024 Sep 21.

引用本文的文献

1
Gastrointestinal stromal tumors with atypical features and presentations: A case series.具有非典型特征和表现的胃肠道间质瘤:病例系列
Int J Surg Case Rep. 2025 Jun 26;133:111569. doi: 10.1016/j.ijscr.2025.111569.

本文引用的文献

1
Exploring Perforated Jejunal GIST: A Rare Case Report and Review of Molecular and Clinical Literature.探索空肠穿孔性胃肠道间质瘤:一例罕见病例报告及分子与临床文献综述
Curr Issues Mol Biol. 2024 Feb 1;46(2):1192-1207. doi: 10.3390/cimb46020076.
2
The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines.SCARE 2023 指南:更新共识外科病例报告(SCARE)指南。
Int J Surg. 2023 May 1;109(5):1136-1140. doi: 10.1097/JS9.0000000000000373.
3
Resection of GIST in the duodenum and proximal jejunum: A retrospective analysis of outcomes.
十二指肠和近端空肠 GIST 的切除术:结果的回顾性分析。
Eur J Surg Oncol. 2019 Oct;45(10):1950-1956. doi: 10.1016/j.ejso.2019.05.002. Epub 2019 May 3.
4
Recent advances in managing gastrointestinal stromal tumor.胃肠道间质瘤治疗的最新进展
F1000Res. 2017 Sep 14;6:1689. doi: 10.12688/f1000research.11118.1. eCollection 2017.
5
Spontaneous rupture of a giant gastrointestinal stromal tumor of the jejunum: a case report and literature review.空肠巨大胃肠道间质瘤自发性破裂:一例报告并文献复习
World J Surg Oncol. 2014 May 21;12:153. doi: 10.1186/1477-7819-12-153.
6
Gastrointestinal stromal tumors (GIST) related emergencies.胃肠道间质瘤(GIST)相关急症。
Int J Surg. 2014;12(4):269-80. doi: 10.1016/j.ijsu.2014.02.004. Epub 2014 Feb 12.
7
Gastrointestinal stromal tumour.胃肠道间质瘤。
Lancet. 2013 Sep 14;382(9896):973-83. doi: 10.1016/S0140-6736(13)60106-3. Epub 2013 Apr 24.
8
Perforated gastrointestinal stromal tumor in the jejunum: A rare cause of acute abdomen.空肠穿孔性胃肠道间质瘤:急腹症的罕见病因。
Oncol Lett. 2012 Dec;4(6):1244-1246. doi: 10.3892/ol.2012.917. Epub 2012 Sep 14.
9
Small intestine gastrointestinal stromal tumors.小肠胃肠道间质瘤。
Curr Opin Gastroenterol. 2012 Mar;28(2):113-23. doi: 10.1097/MOG.0b013e32834ec154.
10
Synchronous gastrointestinal stromal tumors (GIST) and other primary cancers: case series of a single institution experience.同步胃肠道间质瘤(GIST)和其他原发性癌症:单一机构经验的病例系列。
Int J Surg. 2010;8(4):314-7. doi: 10.1016/j.ijsu.2010.03.008. Epub 2010 Apr 7.