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Glepaglutide, a novel long-acting glucagon-like peptide-2 analogue, for patients with short bowel syndrome: a randomised phase 2 trial.格列帕利肽，一种新型长效胰高血糖素样肽-2 类似物，用于治疗短肠综合征患者：一项随机 2 期临床试验。
Lancet Gastroenterol Hepatol. 2019 May;4(5):354-363. doi: 10.1016/S2468-1253(19)30077-9. Epub 2019 Mar 15.
2
GLP-2 analog teduglutide significantly reduces need for parenteral nutrition and stool frequency in a real-life setting.胰高血糖素样肽-2类似物替度鲁肽在实际应用中显著降低了肠外营养需求和排便频率。
Therap Adv Gastroenterol. 2018 Aug 30;11:1756284818793343. doi: 10.1177/1756284818793343. eCollection 2018.
3
Long-Term Therapy With Teduglutide in Parenteral Support-Dependent Patients With Short Bowel Syndrome: A Case Series.肠外营养依赖的短肠综合征患者长期给予特杜古肽治疗：病例系列研究。
JPEN J Parenter Enteral Nutr. 2018 May;42(4):821-825. doi: 10.1002/jpen.1149. Epub 2018 Mar 30.
4
Outcomes from a 12-Week, Open-Label, Multicenter Clinical Trial of Teduglutide in Pediatric Short Bowel Syndrome.替度鲁肽治疗小儿短肠综合征的12周开放标签多中心临床试验结果
J Pediatr. 2017 Feb;181:102-111.e5. doi: 10.1016/j.jpeds.2016.10.027. Epub 2016 Nov 15.
5
Long-Term Teduglutide for the Treatment of Patients With Intestinal Failure Associated With Short Bowel Syndrome.长效替度鲁肽治疗短肠综合征相关肠衰竭患者
Clin Transl Gastroenterol. 2016 Feb 4;7(2):e142. doi: 10.1038/ctg.2015.69.
6
Safety and efficacy of teduglutide after 52 weeks of treatment in patients with short bowel intestinal failure.52 周治疗后短肠肠衰竭患者接受特杜格鲁肽治疗的安全性和疗效。
Clin Gastroenterol Hepatol. 2013 Jul;11(7):815-23.e1-3. doi: 10.1016/j.cgh.2012.12.029. Epub 2013 Jan 17.
7
Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure.特度鲁肽可减少短肠综合征伴肠衰竭患者对肠外支持的需求。
Gastroenterology. 2012 Dec;143(6):1473-1481.e3. doi: 10.1053/j.gastro.2012.09.007. Epub 2012 Sep 11.
8
Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome.随机安慰剂对照试验研究特杜格鲁肽减少短肠综合征患者肠外营养和/或静脉输液需求的作用。
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9
Growth factors: possible roles for clinical management of the short bowel syndrome.生长因子：在短肠综合征临床管理中的潜在作用
Semin Pediatr Surg. 2010 Feb;19(1):35-43. doi: 10.1053/j.sempedsurg.2009.11.010.
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Guidelines for pharmacotherapy, nutritional management, and weaning parenteral nutrition in adult patients with short bowel syndrome: introduction.
J Clin Gastroenterol. 2006 May-Jun;40 Suppl 2:S73-4. doi: 10.1097/01.mcg.0000212676.29420.ff.

胰高血糖素样肽-2类似物作为肠道衰竭的首个特异性治疗方法。

GLP-2 Analogues as First Specific Treatment of Intestinal Failure.

作者信息

Blumenstein Irina

机构信息

Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Frankfurt, Frankfurt am Main, Germany.

出版信息

Visc Med. 2019 Oct;35(5):320-323. doi: 10.1159/000503043. Epub 2019 Sep 25.

DOI:10.1159/000503043
PMID:31768396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6873062/
Abstract

Growth factors and other trophic hormones play an important role in the specific treatment of intestinal failure, with teduglutide being the first approved medication specifically for use in patients with intestinal failure in conjunction with specialized nutritional support. This article focusses on the mode of action, the pivotal study data, treatment response prediction as well as new substances in phase clinical trials.

摘要

生长因子和其他营养激素在肠道衰竭的特异性治疗中发挥着重要作用，替度鲁肽是首个获批专门用于肠道衰竭患者并联合特殊营养支持的药物。本文重点关注其作用模式、关键研究数据、治疗反应预测以及处于临床试验阶段的新物质。