McMellen Mark E, Wakeman Derek, Longshore Shannon W, McDuffie Lucas A, Warner Brad W
Division of Pediatric Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Semin Pediatr Surg. 2010 Feb;19(1):35-43. doi: 10.1053/j.sempedsurg.2009.11.010.
The structural and functional changes during intestinal adaptation are necessary to compensate for the sudden loss of digestive and absorptive capacity after massive intestinal resection. When the adaptive response is inadequate, short bowel syndrome (SBS) ensues and patients are left with the requirement for parenteral nutrition and its associated morbidities. Several hormones have been studied as potential enhancers of the adaptation process. The effects of growth hormone, insulin-like growth factor-1, epidermal growth factor, and glucagon-like peptide 2 on adaptation have been studied extensively in animal models. In addition, growth hormone and glucagon-like peptide 2 have shown promise for the treatment of SBS in clinical trials in human beings. Several lesser studied hormones, including leptin, corticosteroids, thyroxine, testosterone, and estradiol, are also discussed.
肠道适应过程中的结构和功能变化对于弥补大规模肠道切除术后消化和吸收能力的突然丧失是必要的。当适应性反应不足时，就会发生短肠综合征（SBS），患者需要接受肠外营养及其相关的并发症。几种激素已被作为适应性过程的潜在增强剂进行研究。生长激素、胰岛素样生长因子-1、表皮生长因子和胰高血糖素样肽2对适应性的影响已在动物模型中进行了广泛研究。此外，生长激素和胰高血糖素样肽2在人类临床试验中已显示出治疗SBS的前景。还讨论了几种研究较少的激素，包括瘦素、皮质类固醇、甲状腺素、睾酮和雌二醇。
