Yes相关蛋白（YAP）促进糖尿病心脏压力超负荷诱导的功能障碍。

Ikeda Shohei, Mukai Risa, Mizushima Wataru, Zhai Peiyong, Oka Shin-Ichi, Nakamura Michinari, Del Re Dominic P, Sciarretta Sebastiano, Hsu Chiao-Po, Shimokawa Hiroaki, Sadoshima Junichi

Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey.

Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

JACC Basic Transl Sci. 2019 Sep 23;4(5):611-622. doi: 10.1016/j.jacbts.2019.05.006. eCollection 2019 Sep.

Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and YAP plays an essential role in mediating the exacerbation of heart failure in response to pressure overload in the hearts of mice fed a high-fat diet. YAP induced dedifferentiation of cardiomyocytes through activation of transcriptional enhancer factor 1 (TEAD1), a transcription factor. Thus, YAP and TEAD1 are promising therapeutic targets for diabetic patients with high blood pressure to prevent the development of heart failure.

与没有糖尿病的患者相比，糖尿病患者在高血压情况下更容易发生心力衰竭。Yes相关蛋白（YAP）是Hippo信号通路的关键效应因子，在糖尿病心脏中持续激活，并且YAP在介导高脂饮食喂养小鼠心脏压力过载时心力衰竭的加重中起重要作用。YAP通过激活转录增强因子1（TEAD1，一种转录因子）诱导心肌细胞去分化。因此，YAP和TEAD1是高血压糖尿病患者预防心力衰竭发生的有前景的治疗靶点。