National Traditional Chinese Medicine Clinical Research Base and Department of Cardiovascular Medicine, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Cardiovasc Toxicol. 2024 Dec;24(12):1410-1427. doi: 10.1007/s12012-024-09926-6. Epub 2024 Oct 4.
The Hippo-yes-associated protein (YAP) signaling pathway plays a crucial role in cell proliferation, differentiation, and death. It is known to have impact on the progression and development of cardiovascular diseases (CVDs) as well as in the regeneration of cardiomyocytes (CMs). However, further research is needed to understand the molecular mechanisms by which the Hippo-YAP pathway affects the pathological processes of CVDs in order to evaluate its potential clinical applications. In this review, we have summarized the recent findings on the role of the Hippo-YAP pathway in CVDs such as myocardial infarction, heart failure, and cardiomyopathy, as well as its in CM development. This review calls attention to the potential roles of the Hippo-YAP pathway as a relevant target for the future treatment of CVDs.
Hippo-yes 相关蛋白 (YAP) 信号通路在细胞增殖、分化和死亡中发挥着关键作用。已知其对心血管疾病 (CVDs) 的进展和发展以及心肌细胞 (CMs) 的再生有影响。然而，需要进一步的研究来了解 Hippo-YAP 通路影响 CVDs 病理过程的分子机制，以便评估其潜在的临床应用。在这篇综述中，我们总结了 Hippo-YAP 通路在心肌梗死、心力衰竭和心肌病等 CVDs 中的作用及其在 CM 发育中的最新发现。这篇综述提醒人们注意 Hippo-YAP 通路作为未来 CVDs 治疗的相关靶点的潜在作用。
