Kostadinova Lenche, Shive Carey L, Anthony Donald D
¹Department of Medicine, University Hospitals Medical Center, and the Center for AIDS Research, Case Western Reserve University, Cleveland, OH zip code44106, USA.
²The Louis Stokes VA medical Center, Cleveland, 44106, USA.
Cancers (Basel). 2019 Nov 25;11(12):1867. doi: 10.3390/cancers11121867.
Circulating autotaxin (ATX) is elevated in persons with liver disease, particularly in the setting of chronic hepatitis C virus (HCV) and HCV/HIV infection. It is thought that plasma ATX levels are, in part, attributable to impaired liver clearance that is secondary to fibrotic liver disease. In a discovery data set, we identified plasma ATX to be associated with parameters of systemic immune activation during chronic HCV and HCV/HIV infection. We and others have observed a partial normalization of ATX levels within months of starting interferon-free direct-acting antiviral (DAA) HCV therapy, consistent with a non-fibrotic liver disease contribution to elevated ATX levels, or HCV-mediated hepatocyte activation. Relationships between ATX, lysophosphatidic acid (LPA) and parameters of systemic immune activation will be discussed in the context of HCV infection, age, immune health, liver health, and hepatocellular carcinoma (HCC).
循环中的自分泌运动因子（ATX）在肝病患者中升高，尤其是在慢性丙型肝炎病毒（HCV）和HCV/人类免疫缺陷病毒（HIV）感染的情况下。据认为，血浆ATX水平部分归因于继发于肝纤维化疾病的肝脏清除功能受损。在一个发现数据集中，我们确定血浆ATX与慢性HCV和HCV/HIV感染期间的全身免疫激活参数相关。我们和其他人观察到，在开始无干扰素直接抗病毒（DAA）HCV治疗后的几个月内，ATX水平部分恢复正常，这与非纤维化肝病对ATX水平升高的影响或HCV介导的肝细胞激活一致。将在HCV感染、年龄、免疫健康、肝脏健康和肝细胞癌（HCC）的背景下讨论ATX、溶血磷脂酸（LPA）与全身免疫激活参数之间的关系。
