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Early Disruption of VEGF Receptor Signaling and the Risk for Adult Emphysema.

作者信息

Le Cras Timothy D, Abman Steven H

机构信息

University of Cincinnati School of MedicineCincinnati, Ohio.

Cincinnati Children's HospitalCincinnati, Ohioand.

出版信息

Am J Respir Crit Care Med. 2020 Mar 1;201(5):620-621. doi: 10.1164/rccm.201909-1698LE.

DOI:10.1164/rccm.201909-1698LE
PMID:31769719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7047451/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d146/7047451/032b79287ea6/rccm.201909-1698LE_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d146/7047451/032b79287ea6/rccm.201909-1698LE_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d146/7047451/032b79287ea6/rccm.201909-1698LE_f1.jpg

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本文引用的文献

1
Emphysema Is-at the Most-Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension.在Sugen/低氧大鼠肺动脉高压模型中,肺气肿至多只是一种轻微的表型。
Am J Respir Crit Care Med. 2019 Dec 1;200(11):1447-1450. doi: 10.1164/rccm.201906-1200LE.
2
Severe Emphysema in the SU5416/Hypoxia Rat Model of Pulmonary Hypertension.SU5416/低氧性肺动脉高压大鼠模型中的重度肺气肿
Am J Respir Crit Care Med. 2019 Aug 15;200(4):515-518. doi: 10.1164/rccm.201902-0390LE.
3
Intrauterine hypertension decreases lung VEGF expression and VEGF inhibition causes pulmonary hypertension in the ovine fetus.
宫内高血压会降低肺血管内皮生长因子(VEGF)的表达,而抑制VEGF会导致绵羊胎儿患肺动脉高压。
Am J Physiol Lung Cell Mol Physiol. 2003 Mar;284(3):L508-17. doi: 10.1152/ajplung.00135.2002. Epub 2002 Nov 22.
4
Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure.用血管内皮生长因子(VEGF)受体抑制剂治疗新生大鼠会导致肺动脉高压和肺结构异常。
Am J Physiol Lung Cell Mol Physiol. 2002 Sep;283(3):L555-62. doi: 10.1152/ajplung.00408.2001.
5
Inhibition of VEGF receptors causes lung cell apoptosis and emphysema.抑制血管内皮生长因子受体可导致肺细胞凋亡和肺气肿。
J Clin Invest. 2000 Dec;106(11):1311-9. doi: 10.1172/JCI10259.
6
Inhibition of angiogenesis decreases alveolarization in the developing rat lung.抑制血管生成会减少发育中大鼠肺的肺泡化。
Am J Physiol Lung Cell Mol Physiol. 2000 Sep;279(3):L600-7. doi: 10.1152/ajplung.2000.279.3.L600.