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Emphysema Is-at the Most-Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension.

作者信息

Bogaard Harm J, Legchenko Ekaterina, Chaudhary Ketul R, Sun Xiao-Qing, Stewart Duncan J, Hansmann Georg

机构信息

Amsterdam UMCAmsterdam, the Netherlands.

Hannover Medical SchoolHannover, Germanyand.

出版信息

Am J Respir Crit Care Med. 2019 Dec 1;200(11):1447-1450. doi: 10.1164/rccm.201906-1200LE.

DOI:10.1164/rccm.201906-1200LE
PMID:31437404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6884056/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e557/6884056/18d22497224c/rccm.201906-1200LE_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e557/6884056/18d22497224c/rccm.201906-1200LE_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e557/6884056/18d22497224c/rccm.201906-1200LE_f1.jpg

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2
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本文引用的文献

1
Severe Emphysema in the SU5416/Hypoxia Rat Model of Pulmonary Hypertension.SU5416/低氧性肺动脉高压大鼠模型中的重度肺气肿
Am J Respir Crit Care Med. 2019 Aug 15;200(4):515-518. doi: 10.1164/rccm.201902-0390LE.
2
PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation.过氧化物酶体增殖物激活受体γ激动剂吡格列酮通过脂肪酸氧化逆转肺动脉高压并预防右心衰竭。
Sci Transl Med. 2018 Apr 25;10(438). doi: 10.1126/scitranslmed.aao0303.
3
Role of the Aryl Hydrocarbon Receptor in Sugen 5416-induced Experimental Pulmonary Hypertension.
PLoS One. 2020 Oct 15;15(10):e0240692. doi: 10.1371/journal.pone.0240692. eCollection 2020.
4
Update in Pulmonary Vascular Diseases and Right Ventricular Dysfunction 2019.2019年肺血管疾病与右心室功能障碍的进展
Am J Respir Crit Care Med. 2020 Jul 1;202(1):22-28. doi: 10.1164/rccm.202003-0576UP.
5
Early Disruption of VEGF Receptor Signaling and the Risk for Adult Emphysema.血管内皮生长因子受体信号传导的早期破坏与成人肺气肿风险
Am J Respir Crit Care Med. 2020 Mar 1;201(5):620-621. doi: 10.1164/rccm.201909-1698LE.
6
The Adult Sprague-Dawley Sugen-Hypoxia Rat Is Still "the One:" A Model of Group 1 Pulmonary Hypertension: Reply to Le Cras and Abman.成年Sprague-Dawley Sugen-低氧大鼠仍是“首选”：1型肺动脉高压模型：对勒·克拉斯和阿布曼的回复
Am J Respir Crit Care Med. 2020 Mar 1;201(5):621-624. doi: 10.1164/rccm.201910-1983LE.
芳基烃受体在 Sugen 5416 诱导的实验性肺动脉高压中的作用。
Am J Respir Cell Mol Biol. 2018 Mar;58(3):320-330. doi: 10.1165/rcmb.2017-0260OC.
4
Translating Research into Improved Patient Care in Pulmonary Arterial Hypertension.将肺动脉高压研究转化为改善患者护理
Am J Respir Crit Care Med. 2017 Mar 1;195(5):583-595. doi: 10.1164/rccm.201607-1515PP.
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Eur Respir J. 2016 Oct;48(4):1137-1149. doi: 10.1183/13993003.00773-2015. Epub 2016 Jul 28.
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Marked Strain-Specific Differences in the SU5416 Rat Model of Severe Pulmonary Arterial Hypertension.严重肺动脉高压SU5416大鼠模型中显著的品系特异性差异。
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Eur Respir J. 2014 Jul;44(1):160-8. doi: 10.1183/09031936.00204813. Epub 2014 May 2.
8
Formation of plexiform lesions in experimental severe pulmonary arterial hypertension.实验性重度肺动脉高压中丛状病变的形成。
Circulation. 2010 Jun 29;121(25):2747-54. doi: 10.1161/CIRCULATIONAHA.109.927681. Epub 2010 Jun 14.
9
Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension.抑制血管内皮生长因子受体2并结合慢性缺氧会导致细胞死亡依赖性肺内皮细胞增殖和严重的肺动脉高压。
FASEB J. 2001 Feb;15(2):427-38. doi: 10.1096/fj.00-0343com.
10
Inhibition of VEGF receptors causes lung cell apoptosis and emphysema.抑制血管内皮生长因子受体可导致肺细胞凋亡和肺气肿。
J Clin Invest. 2000 Dec;106(11):1311-9. doi: 10.1172/JCI10259.