Department of Orthopaedic Surgery, Shimoshizu National Hospital, Yotsukaido, Japan.
Department of Orthopaedic Surgery, Chiba Qiball clinic, Chuo-ku, Japan.
J Women Aging. 2021 May-Jun;33(3):328-340. doi: 10.1080/08952841.2019.1697161. Epub 2019 Nov 26.
The aim of this study was to determine whether advanced glycation end products (AGEs) revealed by skin autofluorescence (SAF), serum and urine pentosidine level, and serum homocysteine level can serve as a biomarker for sarcopenia in older women. The participants were 70 elderly women. The AGEs pentosidine, homocysteine, and SAF were measured as aging markers. This study shows that among the biomarkers for aging, serum pentosidine correlates with a loss of appendicular lean mass and can serve as a biomarker for sarcopenia. Moreover, SAF and homocysteine values exhibited a positive correlation with age and correlated with each other.: AGEs: advanced glycation end products; BIA: bioelectrical impedance analyzer; BMD: bone mineral density; DLS: degenerative lumbar scoliosis; DXA: dual-energy X-ray absorptiometry; ELISA: enzyme-linked immunoassay; HHcy: hyperhomocysteinemia; RIA: radioimmunoassay; SAF: skin autofluorescence; SMI: skeletal muscle mass index; T2DM: type 2 diabetes patients.
本研究旨在确定皮肤自发荧光（SAF）、血清和尿液戊糖素水平以及血清同型半胱氨酸水平所揭示的晚期糖基化终产物（AGEs）是否可以作为老年女性肌少症的生物标志物。参与者为 70 名老年女性。AGEs 戊糖素、同型半胱氨酸和 SAF 被作为衰老标志物进行了测量。本研究表明，在衰老标志物中，血清戊糖素与四肢瘦体重的丧失相关，可作为肌少症的生物标志物。此外，SAF 和同型半胱氨酸值与年龄呈正相关，并且彼此相关。
