Coiro V, Roti E, d'Amato L, Alboni A, Gardini E, Salvi M, Cersosimo G, Bianconi L, Zanardi G, Bacchi-Modena A
University Clinic of Internal Medicine, School of Medicine, University of Parma, Italy.
Gynecol Endocrinol. 1988 Mar;2(1):35-43. doi: 10.3109/09513598809029337.
In order to determine whether dopamine plays a role in the control of neuropituitary function in pregnant women during labour, blood levels of nicotine (NSN)- and estrogen (ESN)-stimulated neurophysins were measured in 119 women treated orally with placebo (n = 59, control group) or 5 mg bromocriptine, a potent dopaminergic receptor agonist (n = 60, experimental group). Serum samples were taken before drug ingestion (basal sample) and at delivery. The serum basal concentrations of NSN and ESN were similar in both groups of pregnant women in labour. At delivery, serum ESN levels were similar in all women regardless of the treatment, whereas NSN concentrations were significantly lower in the bromocriptine-treated women than in those who were given placebo. In additional experiments the effect of 5 mg bromocriptine on the serum concentrations of NSN and ESN was tested for 6 hours after drug ingestion in 10 healthy, non-pregnant women and in 8 women in the 3rd trimester of pregnancy. Bromocriptine did not modify the circulating levels of NSN and ESN in either of these 2 groups of women. Since NSN and ESN are thought to be associated with vasopressin and oxytocin, respectively, these results indicate that in non-pregnant women and in pregnant women during late pregnancy dopaminergic stimulation with a dopaminergic receptor agonist does not inhibit the release of either vasopressin or oxytocin during rest. In contrast, dopaminergic receptor stimulation appears to play an inhibitory role in the regulation of vasopressin, but not oxytocin secretion in pregnant women in labour.
为了确定多巴胺是否在分娩期间孕妇神经垂体功能的控制中发挥作用，对119名口服安慰剂（n = 59，对照组）或5毫克溴隐亭（一种强效多巴胺能受体激动剂，n = 60，实验组）治疗的女性，测量了尼古丁（NSN）和雌激素（ESN）刺激的神经垂体素的血液水平。在服药前（基础样本）和分娩时采集血清样本。两组分娩期孕妇的NSN和ESN血清基础浓度相似。分娩时，所有女性的血清ESN水平无论治疗情况如何均相似，而溴隐亭治疗组女性的NSN浓度显著低于服用安慰剂的女性。在另外的实验中，对10名健康非孕妇和8名妊娠晚期孕妇在服用药物后6小时测试了5毫克溴隐亭对NSN和ESN血清浓度的影响。溴隐亭在这两组女性中均未改变NSN和ESN的循环水平。由于NSN和ESN分别被认为与血管加压素和催产素相关，这些结果表明，在非孕妇和妊娠晚期孕妇中，用多巴胺能受体激动剂进行多巴胺能刺激在静息时不会抑制血管加压素或催产素的释放。相反，多巴胺能受体刺激在分娩期孕妇血管加压素的调节中似乎起抑制作用，但对催产素分泌不起抑制作用。
