Neurology Department, West China Hospital, Sichuan University, Chengdu, China.
Eur J Neurol. 2020 Apr;27(4):653-659. doi: 10.1111/ene.14132. Epub 2019 Dec 23.
The pathophysiology of Parkinson's disease (PD) remains unclear. Voxel-based morphometry (VBM) detects local structural differences in brain tissue such as grey matter volume (GMV) between groups, which is helpful in understanding the pathophysiology of PD. Published VBM studies of GMV changes in PD have shown inconsistent results. Therefore, a voxel-wise meta-analysis of VBM studies was conducted to detect consistent GMV changes in PD.
The published literature was searched comparing whole-brain GMV between PD patients and healthy controls (HCs) using VBM. Coordinates were extracted for the clusters of significant GMV differences between PD patients and HCs. The meta-analysis was performed by seed-based d mapping software.
A total of 63 studies with 2867 PD patients and 1990 HCs were included. Significant GMV reductions in some brain regions were detected in PD patients, which were involved in the basal ganglia, theory of mind, vocal and visual networks. These findings remained largely unchanged in the jackknife sensitivity analysis, and no significant heterogeneity or publication bias was detected.
Parkinson's disease patients have GMV reductions in a number of brain regions involved in specific networks. These findings provide morphological evidence for the pathophysiology of PD.
帕金森病（PD）的病理生理学仍不清楚。体素形态计量学（VBM）可检测脑组织的局部结构差异，例如灰质体积（GMV），这有助于了解 PD 的病理生理学。已发表的关于 PD 中 GMV 变化的 VBM 研究结果不一致。因此，进行了基于体素的 VBM 研究的荟萃分析，以检测 PD 中一致的 GMV 变化。
使用 VBM 比较 PD 患者和健康对照者（HCs）全脑 GMV，搜索已发表的文献。提取 PD 患者和 HCs 之间 GMV 差异有统计学意义的簇的坐标。采用基于种子的 d 映射软件进行荟萃分析。
共纳入 63 项研究，包括 2867 名 PD 患者和 1990 名 HCs。PD 患者存在一些脑区 GMV 减少，这些脑区涉及基底节、心理理论、发声和视觉网络。在 Jackknife 敏感性分析中，这些发现基本保持不变，且未检测到显著的异质性或发表偏倚。
PD 患者存在多个特定网络涉及的脑区 GMV 减少。这些发现为 PD 的病理生理学提供了形态学证据。
