University of Texas Health Science Center San Antonio, Long School of Medicine, San Antonio, TX 78229.
University of Texas Health Science Center San Antonio, Department of Urology, San Antonio, TX 78229.
Urology. 2020 Feb;136:9-18. doi: 10.1016/j.urology.2019.09.058. Epub 2019 Nov 23.
For prostate cancer, we review racial differences in incidence, androgen pathways, growth factors, tumor location, rate of definitive treatment, and outcomes. We review the effect of race on risk-stratification and discuss studies of active surveillance in the African American population. For bladder cancer, race- and gender- associated differences in incidence, sex hormone pathways. For renal cell carcinoma, disparities in incidence, genetic factors, tumor pathology, time to presentation, and disease specific survival have been observed. We evaluate the impact of race and ethnicity on tumor pathology and discuss gaps in our current understanding of renal cell carcinoma pathogenesis.
对于前列腺癌,我们回顾了发病率、雄激素途径、生长因子、肿瘤位置、确定性治疗率和结果方面的种族差异。我们回顾了种族对风险分层的影响,并讨论了非裔美国人人群中主动监测的研究。对于膀胱癌,种族和性别相关的发病率、性激素途径存在差异。对于肾细胞癌,发病率、遗传因素、肿瘤病理学、就诊时间和疾病特异性生存方面存在差异。我们评估了种族和民族对肿瘤病理学的影响,并讨论了我们目前对肾细胞癌发病机制理解的差距。