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韩国儿童上睑下垂的患病率及危险因素:韩国国家健康和营养检查调查。

Prevalence and risk factors of childhood blepharoptosis in Koreans: the Korea National Health and Nutrition Examination Survey.

机构信息

Department of Ophthalmology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.

Interdisciplinary Program in Medical Informatics, Seoul National University College of Medicine, Seoul, Korea.

出版信息

Eye (Lond). 2020 Sep;34(9):1585-1591. doi: 10.1038/s41433-019-0697-3. Epub 2019 Nov 26.

Abstract

PURPOSE

Childhood blepharoptosis may cause cosmetic and functional problems in children, but there is a paucity of studies about its epidemiology. This study aimed to investigate the prevalence of childhood blepharoptosis and associated risk factors in a representative Korean population.

METHODS

This cross-sectional nation-wide study analysed the data set acquired from the Korea National Health and Nutrition Examination Survey 2008-2012. A total of 8218 children aged 3-18 years were included. The prevalence of childhood blepharoptosis, defined as a margin reflex distance (MRD) of < 2 mm in either eye, was estimated, and the risk factors were identified using multivariate logistic regression analysis.

RESULTS

The mean age of participants was 11.3 ± 0.1 years, and 52.8 ± 0.6% were boys. The overall prevalence of childhood blepharoptosis in Korea was 8.0% (95% CI, 6.9-9.1%). Boys exhibited a higher prevalence of blepharoptosis than girls at most of ages. Levator function increased with age in the normal general population. The proportion of subjects exhibiting MRD1 ≥ 4.0 mm also increased significantly with age (p < 0.001). Male gender, higher body mass index, and urban residency were significantly associated with childhood blepharoptosis.

CONCLUSIONS

The prevalence of childhood blepharoptosis is higher in urban obese boys. The increase of levator function with age should be considered in evaluations of childhood ptosis.

摘要

目的

儿童上睑下垂可能导致儿童出现美容和功能问题,但关于其流行病学的研究甚少。本研究旨在调查韩国代表性人群中儿童上睑下垂的患病率及其相关危险因素。

方法

本横断面全国性研究分析了 2008-2012 年韩国国家健康和营养检查调查获得的数据集。共纳入 8218 名 3-18 岁儿童。估计儿童上睑下垂的患病率(定义为双眼的睑裂距 < 2mm),并使用多变量 logistic 回归分析确定危险因素。

结果

参与者的平均年龄为 11.3±0.1 岁,其中 52.8%±0.6%为男孩。韩国儿童上睑下垂的总患病率为 8.0%(95%CI,6.9-9.1%)。在大多数年龄段,男孩的上睑下垂患病率均高于女孩。在正常普通人群中,提上睑肌功能随年龄增长而增加。表现为 MRD1≥4.0mm 的受试者比例也随年龄显著增加(p<0.001)。男性、较高的体重指数和城市居住与儿童上睑下垂显著相关。

结论

城市肥胖男孩的儿童上睑下垂患病率较高。在评估儿童上睑下垂时,应考虑随年龄增长提上睑肌功能的增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b5/7609679/1732044e21e9/41433_2019_697_Fig1_HTML.jpg

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