Department of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 10, 63-ro, Yeongdeungpo-gu, Seoul, 07345, Republic of Korea.
Eyeclinic, Center for Clinical Center, National Cancer Center, Goyang-si, South Korea.
Sci Rep. 2022 Jan 10;12(1):389. doi: 10.1038/s41598-021-04381-7.
Cataract and blepharoptosis are both commonly encountered ophthalmic problems in older adults. Since they share similar risk factors, it is plausible that there may be an association between the two conditions. We examined data from the Korean National Health and Nutrition Examination Survey (KNHANES) 2010-2012 to determine if there is an association between age-related cataract and blepharoptosis. Multivariable adjusted logistic regression analysis was conducted to examine the odds ratio (OR) and 95% confidence interval (CI) for association of each specific type of cataract with presence of blepharoptosis. Of the 10,387 eligible participants, 4782 (46.0%) had cataract and 1419 (15.8%) had blepharoptosis. There were more participants with blepharoptosis in the cataract group, compared with those in the no cataract group. After adjusting for potential confounders, participants with blepharoptosis had a higher risk of total cataract (OR: 1.557, 95% CI 1.201-2.019) and nuclear subtype cataract (OR: 1.305, 95% CI 1.050-1.620). Blepharoptosis was associated with significantly higher odds of cataract in obese participants when compared with non-obese participants (p for interaction = 0.0236). Our study revealed a positive association between age-related cataract and blepharoptosis; it suggests that thorough ophthalmic assessment is needed when assessing patients who are planning cataract or blepharoptosis surgery.
白内障和眼睑下垂都是老年人常见的眼科问题。由于它们有相似的危险因素，因此这两种疾病之间可能存在关联。我们研究了 2010-2012 年韩国国家健康和营养调查（KNHANES）的数据，以确定年龄相关性白内障与眼睑下垂之间是否存在关联。我们采用多变量调整逻辑回归分析来检查每种特定类型白内障与眼睑下垂存在之间的比值比（OR）和 95%置信区间（CI）。在 10387 名合格参与者中，有 4782 名（46.0%）患有白内障，1419 名（15.8%）患有眼睑下垂。与无白内障组相比，白内障组中有更多的参与者患有眼睑下垂。在调整了潜在混杂因素后，患有眼睑下垂的参与者患总白内障（OR：1.557，95%CI 1.201-2.019）和核型白内障（OR：1.305，95%CI 1.050-1.620）的风险更高。与非肥胖参与者相比，肥胖参与者中眼睑下垂与白内障的相关性更高（交互检验 p 值=0.0236）。我们的研究揭示了年龄相关性白内障与眼睑下垂之间存在正相关；这表明在评估计划进行白内障或眼睑下垂手术的患者时，需要进行全面的眼科评估。
