Lazarova M, Przewłocka B, Mogilnicka E, Stala L
Pol J Pharmacol Pharm. 1979 Nov-Dec;31(6):547-54.
Electrolytic lesions of the median raphe nucleus and substantia nigra markedly increased susceptibility to pentetrazole seizures in rats. L-5-hydroxytryptophan, considerably increasing the serotonin (5-HT) level in the brain, markedly inhibited the seizures and abolished the seizure-enhanced effect of lesion of the substantia nigra. L-DOPA tended to potentiate the seizures-enhancing effect produced by lesions of the median raphe nucleus. The changes in the brain 5-HT level and the intensity of pentetrazole seizures were correlated. The results indicate that the balance between neurotransmitter systems in the brain is of importance to the susceptibility to pentetrazole convulsions.
中缝正中核和黑质的电解损伤显著增加了大鼠对戊四氮惊厥的易感性。L-5-羟色氨酸可显著提高大脑中血清素（5-HT）水平，明显抑制惊厥，并消除黑质损伤所致的惊厥增强效应。左旋多巴倾向于增强中缝正中核损伤所产生的惊厥增强效应。大脑5-HT水平的变化与戊四氮惊厥的强度相关。结果表明，大脑中神经递质系统之间的平衡对于戊四氮惊厥的易感性很重要。
