Lazarova M B, Roussinov K S
Acta Physiol Pharmacol Bulg. 1978;4(3):50-5.
In experiments with pentylenetetrazol convulsion model it has been found that L-DOPA in a dose of 50 mg/kg has no influence, while 500 mg/kg potentiate convulsions. Amantadine in a dose of 25 mg/kg and particularly markedly in a dose of 100 mg/kg potentaites convulsive seizures. Amphetamine in a dose of 0.5 mg/kg has no effect, while 5 mg/kg potentiate convulsive seizures, which is particularly pronounced in mice. Apomorphine in doses of 0.5 and 5 mg/kg has no marked effect on convulsions. Haloperidol in doses of 0.2 and 2 mg/kg does not have a pronounced effect on convulsive-seizure reactions and does not influence the effect of L-DOPA and amantadine on these reactions. The results obtained suggested a rather indirect effect of the dopaminergic system on convulsive-seizure reactivity. It is possible that the effects of some of the dopaminergic agents studied are realized through influencing the relationships between the dopaminergic system and other neurotransmitter systems (especially cholinergic, GABA-ergic and serotonin-ergic).
在戊四氮惊厥模型实验中发现，50毫克/千克剂量的左旋多巴无影响，而500毫克/千克剂量会增强惊厥。25毫克/千克剂量的金刚烷胺，尤其是100毫克/千克剂量时，会明显增强惊厥发作。0.5毫克/千克剂量的苯丙胺无作用，而5毫克/千克剂量会增强惊厥发作，这在小鼠中尤为明显。0.5毫克/千克和5毫克/千克剂量的阿扑吗啡对惊厥无明显影响。0.2毫克/千克和2毫克/千克剂量的氟哌啶醇对惊厥发作反应无显著影响，且不影响左旋多巴和金刚烷胺对这些反应的作用。所得结果提示多巴胺能系统对惊厥发作反应性有相当间接的影响。所研究的一些多巴胺能药物的作用可能是通过影响多巴胺能系统与其他神经递质系统（尤其是胆碱能、γ-氨基丁酸能和5-羟色胺能系统）之间的关系来实现的。
