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米诺环素相关性黑色甲状腺。

Minocycline-related black thyroid.

作者信息

Hanzlick R, Wilson R

机构信息

Medical Examiner's Office, Fulton County, Atlanta, Georgia.

出版信息

Am J Forensic Med Pathol. 1988 Sep;9(3):201-2. doi: 10.1097/00000433-198809000-00003.

DOI:10.1097/00000433-198809000-00003
PMID:3177345
Abstract

Black pigmentation of the thyroid gland has been observed in patients chronically taking minocycline antibiotics. Pigment changes of the skin, blood vessels, and bone have also been reported. Some of these changes may be caused by traumatic or toxic etiologies, therefore persons conducting forensic death investigations need be aware of minocycline-related changes. This article reviews pigment changes of the thyroid gland and discusses the potential forensic import of such findings.

摘要

长期服用米诺环素类抗生素的患者甲状腺出现了黑色色素沉着。皮肤、血管和骨骼的色素变化也有报道。其中一些变化可能由创伤性或中毒性病因引起,因此进行法医死亡调查的人员需要了解与米诺环素相关的变化。本文回顾了甲状腺的色素变化,并讨论了这些发现的潜在法医意义。

相似文献

1
Minocycline-related black thyroid.米诺环素相关性黑色甲状腺。
Am J Forensic Med Pathol. 1988 Sep;9(3):201-2. doi: 10.1097/00000433-198809000-00003.
2
Black thyroid associated with minocycline therapy: histochemical and ultrastructural studies on the brown pigment.与米诺环素治疗相关的黑色甲状腺:棕色色素的组织化学和超微结构研究
Isr J Med Sci. 1988 Jan;24(1):51-3.
3
Minocycline and the thyroid: antithyroid effects of the drug, and the role of thyroid peroxidase in minocycline-induced black pigmentation of the gland.米诺环素与甲状腺:该药物的抗甲状腺作用,以及甲状腺过氧化物酶在米诺环素诱导的甲状腺黑色色素沉着中的作用。
Thyroid. 1996 Jun;6(3):211-9. doi: 10.1089/thy.1996.6.211.
4
The minocycline-induced thyroid pigment and several synthetic models: identification and characterization by electron paramagnetic resonance spectroscopy.米诺环素诱导的甲状腺色素及几种合成模型:通过电子顺磁共振波谱进行鉴定和表征
J Pharmacol Exp Ther. 1993 Sep;266(3):1164-76.
5
Morphological and biochemical studies on minocycline-induced black thyroid in rats.
Toxicol Appl Pharmacol. 1985 Dec;81(3 Pt 1):393-400. doi: 10.1016/0041-008x(85)90410-7.
6
A black thyroid and minocycline treatment.黑色甲状腺与米诺环素治疗
Br Med J. 1976 Nov 6;2(6044):1109-10. doi: 10.1136/bmj.2.6044.1109.
7
Fine structural aspects of the black thyroid induced by minocycline, and the effects of a low iodine diet, propylthiouracil, thyroxine tablet and TSH, on the black discoloration of the rat thyroid.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1985;48(3):219-27. doi: 10.1007/BF02890130.
8
Minocycline hydrochloride and thyroid pigmentation. A case report with histological and ultrastructural study.盐酸米诺环素与甲状腺色素沉着。一例伴有组织学和超微结构研究的病例报告。
Pathology. 1984 Jul;16(3):339-41. doi: 10.3109/00313028409068548.
9
Black thyroid syndrome: exaggeration of a normal process?
Am J Clin Pathol. 1986 Apr;85(4):411-8. doi: 10.1093/ajcp/85.4.411.
10
Thyroid gland pigmentation and minocycline therapy.甲状腺色素沉着与米诺环素治疗
Am J Pathol. 1984 Oct;117(1):98-109.

引用本文的文献

1
An Overview of the Thyroid Gland and Thyroid-Related Deaths for the Forensic Pathologist.法医病理学家的甲状腺及甲状腺相关死亡概述
Acad Forensic Pathol. 2016 Jun;6(2):217-236. doi: 10.23907/2016.024. Epub 2016 Jun 1.
2
Black thyroid: report of an autopsy case.黑色甲状腺:一例尸检病例报告
Int J Legal Med. 2006 May;120(3):157-9. doi: 10.1007/s00414-005-0028-z. Epub 2005 Sep 6.