Senba M, Toda Y, Yamashita H
Department of Pathology, Nagasaki University, Japan.
Isr J Med Sci. 1988 Jan;24(1):51-3.
The brown pigment found in the black thyroid, associated with minocycline therapy, was studied histochemically and ultrastructurally. The brown pigment was Fontana-Masson silver-positive, and was negative for iron, for autofluorescence under uv illumination, for periodic acid Schiff (PAS) and for acid-fast iodine peroxidase (AFIP) lipofuscin, and was bleached with potassium permanganate. The light and electron microscopic studies suggested that the pigment resembled melanin. Although the mechanism of the pigment deposition is not clear, a possible explanation may be that the pigment is related to direct oxidative degradation products of minocycline.
对与米诺环素治疗相关的黑色甲状腺中发现的棕色色素进行了组织化学和超微结构研究。该棕色色素对Fontana-Masson银染呈阳性，对铁、紫外线照射下的自发荧光、过碘酸希夫（PAS）反应以及抗酸碘过氧化物酶（AFIP）脂褐素呈阴性，并用高锰酸钾漂白。光镜和电镜研究表明该色素类似黑色素。尽管色素沉积的机制尚不清楚，但一种可能的解释是该色素与米诺环素的直接氧化降解产物有关。
