Department of Chemistry, C. Abdul Hakeem College, Melvisharam - 632509, Tamil Nadu, India.
Department of Chemistry, Auxilium College (Autonomous), Vellore - 632006, Tamil Nadu, India.
Curr Drug Res Rev. 2020;12(1):4-15. doi: 10.2174/2589977511666191024173508.
Objective: The stability and delivery of drugs remain one of the key hurdles in the present situation. The present study depends on the design of a novel nanoemulsion drugdelivery system that would encapsulate a drug and to improve drug stability. The charisma of nanotechnology is majorly due to the smallest particle size at the nanoscale.
Nanoemulsions attention is focused on emphasizing formulation aspect, method of preparation characterization techniques, evaluation parameters and various application of the nanoemulsions, several techniques to be used for the preparation of nanoemulsions like microfluidization, high-pressure homogenization, low energy emulsification and solvent evaporation method and their parameters to be characterized.
The design of effective formulations for drugs is being applied to enhance the solubility and bioavailability of water-insoluble drugs. The nanosized droplets have led to considerable attraction for this formulation, for the delivery of hydrophilic as well as hydrophobic drugs as drug carriers because of their improved drug solubilization capacity, long shelf life, ease of preparation and improvement of bioavailability of drugs.
The application of these nanoformulation preparations, limitations, their advantages and disadvantages as nanoemulsions will solve the various problems that current therapeutic agents face and has opened a new scenario to formulate nanoemulsions with various therapeutic agents with heightened competence along with oral drug delivery to treat diseases in the near future.
目的：药物的稳定性和递送仍然是当前面临的主要障碍之一。本研究依赖于设计一种新的纳米乳药物递送系统，该系统将包裹药物并提高药物稳定性。纳米技术的魅力主要在于纳米级的最小粒径。
纳米乳受到关注，重点强调了制剂方面、制备方法、表征技术、评价参数和纳米乳的各种应用，将使用几种技术来制备纳米乳，如微流化、高压匀化、低能量乳化和溶剂蒸发法，以及要表征的参数。
设计有效的药物制剂用于提高水不溶性药物的溶解度和生物利用度。纳米尺寸的液滴因其提高药物溶解度、长保质期、易于制备和改善药物生物利用度的能力，对亲水性和疏水性药物作为药物载体的递送具有相当大的吸引力。
这些纳米制剂的应用，解决了当前治疗剂面临的各种问题，并为各种治疗剂制定纳米乳提供了新的方案，具有更高的能力，同时通过口服药物递送来治疗未来的疾病。
