Department of Anesthesiology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, China.
Department of Anesthesiology, First People's Hospital of Shizuishan City, Shizuishan, China.
Cell Biochem Funct. 2020 Jan;38(1):21-27. doi: 10.1002/cbf.3439. Epub 2019 Nov 27.
Desflurane is one of the commonly used general anaesthetics. Recently, it was reported that desflurane caused neurotoxicity, raising concerns in clinical use. In this study, we found desflurane could affect viability and maturation in motor neurons. Dexmedetomidine, a α2-adrenergic receptor agonist, could attenuate the effect of desflurane on motor neurons. This process was mediated by NF-KappaB signalling. Interestingly, we also found that dexmedetomidine could recover the lesion in motor function and memory impaired by desflurane. Collectively, our results showed the neurotoxic effect of desflurane in motor neurons. More importantly, this process was alleviated by dexmedetomidine, potentially showing its application in protecting motor neuron from neurotoxic agents. Significance of the study: This work provides the evidence to support the protective role of dexmedetomidine in desflurane-induced motor neuron death. Since desflurane is a widely used anaesthetic in surgery and leads to neuron death, the neuroprotective effect of dexmedetomidine holds promising clinical application.
地氟醚是一种常用的全身麻醉剂。最近有报道称地氟醚可引起神经毒性，引起临床使用的关注。在这项研究中，我们发现地氟醚可影响运动神经元的活力和成熟。右美托咪定是一种α2-肾上腺素能受体激动剂，可减轻地氟醚对运动神经元的影响。这个过程是通过 NF-κB 信号传导介导的。有趣的是，我们还发现右美托咪定可以恢复地氟醚引起的运动功能和记忆损伤。综上所述，我们的研究结果表明地氟醚对运动神经元具有神经毒性作用。更重要的是，右美托咪定可减轻该过程，表明其在保护运动神经元免受神经毒性物质方面具有潜在的应用价值。研究意义：本研究为右美托咪定在抑制地氟醚诱导的运动神经元死亡中的保护作用提供了证据。由于地氟醚是手术中广泛使用的麻醉剂，可导致神经元死亡，右美托咪定的神经保护作用具有广阔的临床应用前景。
