Zhao Hui, Bu Meimei, Li Binglu, Zhang Yong
Galactophore Department, The Maternal and Child Health Hospital of Jinan City, Jinan, Shandong, China.
Anesthesia Department, The Maternal and Child Health Hospital of Jinan City, Jinan, Shandong, China.
Tissue Cell. 2018 Feb;50:37-42. doi: 10.1016/j.tice.2017.12.001. Epub 2017 Dec 5.
Desfluraneis a widely-used general anesthetics. However, recent reports showed its significant side effect in the nervous system. Desflurane could lead to the neuronal death and affect the working memory. Unfortunately, the mechanism underlying the action of desflurane is still not clear and there is still no potent medicine to prevent the lesion in the central nervous system caused by general anesthetics. In this study, we found α-lipoic acid, an antioxidant exerting protective effect on multiple cells tissues, could resist the neurotoxicity caused by desflurane exposure. Lipoic acid possessed strong anti-apoptotic effect on the desflurane-treated hippocampal neurons, which was mediated by the Caspase-3 dependent pathway and NF-kappaB signaling. Collectively, we found a promising candidate to be clinically applied in intervention against the damage in nervous system by the desflurane.
地氟烷是一种广泛使用的全身麻醉剂。然而，最近的报告显示其在神经系统中有显著的副作用。地氟烷可导致神经元死亡并影响工作记忆。不幸的是，地氟烷作用的潜在机制仍不清楚，并且仍然没有有效的药物来预防全身麻醉剂引起的中枢神经系统损伤。在本研究中，我们发现α-硫辛酸，一种对多种细胞组织具有保护作用的抗氧化剂，可以抵抗地氟烷暴露引起的神经毒性。硫辛酸对经地氟烷处理的海马神经元具有强大的抗凋亡作用，这是由半胱天冬酶-3依赖性途径和核因子-κB信号传导介导的。总的来说，我们找到了一种有前景的候选药物，可在临床上用于干预地氟烷对神经系统的损伤。
